       Document 0566
 DOCN  M9640566
 TI    SIVsmmPBj14 induces expression of a mucosal integrin on macaque
       lymphocytes.
 DT    9604
 AU    Gummuluru S; Novembre FJ; Seshi B; Dewhurst S; Department of
       Microbiology and Immunology, University of; Rochester Medical Center,
       New York 14642, USA.
 SO    Virology. 1996 Jan 1;215(1):97-100. Unique Identifier : AIDSLINE
       MED/96146746
 AB    The PBj14 isolate of simian immunodeficiency virus, SIVsmmPBj14, is an
       acutely pathogenic lentivirus that causes severe gastrointestinal
       disease in macaque monkeys. The studies reported here examine the basis
       for the enteropathic phenotype of SIVsmmPBj14, using flow cytometric
       analysis of cultured macaque lymphocytes and immunohistochemical
       staining of tissue specimens from virus-infected macaques. The data show
       that enteropathic molecular clones of SIVsmmPBj14 induce expression of
       the alpha E beta 7 integrin, which is believed to mediate mucosal
       retention of T-cells, whereas molecular clones from nonenteropathic
       derivatives of SIVsmmPBj14 do not do so. Thus, elevated expression of
       alpha E beta 7 may ber responsible, at least in part, for the
       accumulation of abnormally large numbers of T-cells within the
       intestinal mucosa during acute SIVsmmPBj14 infection.
 DE    Animal  Cells, Cultured  Human  Integrins/*BIOSYNTHESIS  Intestinal
       Mucosa/*IMMUNOLOGY  Lymphocytes/CYTOLOGY/*IMMUNOLOGY  Macaca  Support,
       U.S. Gov't, P.H.S.  SIV/*IMMUNOLOGY/ISOLATION & PURIF  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

