       Document 0567
 DOCN  M9640567
 TI    Transmission of HIV-1 from productively infected mature Langerhans cells
       to primary CD4+ T lymphocytes results in altered T cell responses with
       enhanced production of IFN-gamma and IL-10.
 DT    9604
 AU    Ludewig B; Gelderblom HR; Becker Y; Schafer A; Pauli G; Robert
       Koch-Institut, Berlin, Germany.
 SO    Virology. 1996 Jan 1;215(1):51-60. Unique Identifier : AIDSLINE
       MED/96146742
 AB    Mature Langerhans cells (mLC), the ex vivo correlates of interdigitating
       dendritic cells (IDC), are susceptible to infection with HIV-1. As IDC
       are important activators of T helper (Th) cells in vivo, we examined the
       interaction of HIV-1-infected mLC with CD4+ T lymphocytes.
       HIV-1-infected mLC readily formed clusters with the T cells and
       efficiently transmitted HIV-1 to the CD4+ Th cells. Formation of
       syncytia between mLC and T cells was initiated by HIV-1-infected mLC. In
       the clusters of HIV-1-infected mLC and activated T cells a massive HIV-1
       production was observed leading to the subsequent elimination of the
       activated and infected T helper cells. Examination of the cytokine
       pattern produced during interaction of infected mLC with CD4+ T cells
       revealed an enhanced production of IFN-gamma and IL-10 in the
       cocultures. These results suggest that during antigen
       presentation-driven T cell activation by IDC in the lymphoid tissues,
       HIV-1-infected IDC might efficiently transmit the virus to Th cells,
       leading to altered Th cell responses.
 DE    Cell Communication  Cell Line  Cells, Cultured  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY/ULTRASTRUCTURE/*VIROLOGY  Giant Cells/VIROLOGY
       Human  HIV-1/DRUG EFFECTS/*PHYSIOLOGY  Interferon Type II/*BIOSYNTHESIS
       Interleukin-10/*BIOSYNTHESIS  Langerhans
       Cells/METABOLISM/ULTRASTRUCTURE/*VIROLOGY  Support, Non-U.S. Gov't
       Tumor Cells, Cultured  Virus Replication/DRUG EFFECTS
       Zidovudine/PHARMACOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

