       Document 0589
 DOCN  M9640589
 TI    [Relationship between Epstein-Barr virus and lymphoproliferative
       syndromes in patients without immunodeficiency]
 DT    9604
 AU    Barranco M; Vidal J; Quintero L; Vives-Corrons JL; Jimenez de Anta MT;
       Servicio de Microbiologia Hospital Clinico y Provincial,; Faeultad de
       Medicina, Universidad de Barcelona.
 SO    Sangre (Barc). 1995 Oct;40(5):383-7. Unique Identifier : AIDSLINE
       MED/96151807
 AB    PURPOSE: The relationship between Epstein-Barr virus (EBV) and
       infectious mononucleosis, pharyngeal carcinoma and Burkitt's lymphoma is
       well known. Further relationship seems to exist between EBV and the
       lymphoproliferative syndromes appearing in immunodeficient subjects. The
       present work is aimed to study the possible relationship between the
       virus and the lymphoproliferative syndromes presented by people without
       any apparent immunodeficiency. PATIENTS AND METHODS: The presence of
       antibodies against different antigens of the virus was analysed.
       Antibodies against the viral capsid antigen were studied along with
       those against the early antigen and the viral core antigen in 55
       patients with lymphoproliferative syndromes, of whom 38 had
       non-Hodgkin's lymphoma and 17 had acute lymphoblastic leukaemia, and
       none of them had immunodeficiency. RESULTS: Significantly higher
       geometric means of the titres against capsid antigen and of the
       prevalence of antibodies against early antigen were seen in the patients
       with non-Hodgkin's lymphoma with respect to the control group. On the
       contrary, patients with acute lymphoblastic leukaemia showed lower
       immunologic response than the control group, although the difference was
       not significant for any of the antibodies under study. CONCLUSIONS: The
       higher immunologic response against EBV and its reactivation in
       non-Hodgkin's lymphoma would suggest that such agent could play a role
       favouring the onset of the disease, if not as a direct aetiological
       factor.
 DE    Adolescence  Adult  Antigens, Viral/ANALYSIS/BLOOD  English Abstract
       Female  Herpesviridae Infections/IMMUNOLOGY  *Herpesvirus 4,
       Human/IMMUNOLOGY/ISOLATION & PURIF  Human  Immunocompetence/IMMUNOLOGY
       Leukemia, Lymphocytic, Acute/IMMUNOLOGY/*VIROLOGY  Lymphoma,
       Non-Hodgkin's/IMMUNOLOGY/*VIROLOGY  Lymphoproliferative
       Disorders/IMMUNOLOGY/*VIROLOGY  Male  Middle Age  Tumor Virus
       Infections/IMMUNOLOGY  Viral Core Proteins/ANALYSIS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

