       Document 0592
 DOCN  M9640592
 TI    Toward an understanding of the correlates of protective immunity to HIV
       infection.
 DT    9604
 AU    Haynes BF; Pantaleo G; Fauci AS; Department of Medicine, Duke Medical
       Center, Durham, NC 27710,; USA.
 SO    Science. 1996 Jan 19;271(5247):324-8. Unique Identifier : AIDSLINE
       MED/96144680
 AB    Considerable progress has been made recently in understanding the
       genetic, immunologic and virologic factors in human immunodeficiency
       virus (HIV)-infected individuals who either rapidly progress or do not
       progress to acquired immunodeficiency syndrome (AIDS). In addition,
       detection of HIV-specific immune responses in HIV-negative individuals
       who have been exposed to the virus multiple times suggests that natural
       immune responses to HIV may be protective in rare individuals.
       Understanding the correlates of protective immunity to HIV infection is
       critical to efforts to develop preventive HIV vaccines as well as to
       determine the feasibility of treating HIV infection by boosting immunity
       to HIV.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/VIROLOGY  Animal  AIDS
       Vaccines  Cytokines/IMMUNOLOGY  CD4-Positive T-Lymphocytes/IMMUNOLOGY
       CD8-Positive T-Lymphocytes/IMMUNOLOGY  Disease Progression  Human
       HIV/IMMUNOLOGY/PHYSIOLOGY  HIV Antibodies/*IMMUNOLOGY  HIV
       Infections/*IMMUNOLOGY/VIROLOGY  HIV Seronegativity/IMMUNOLOGY  Major
       Histocompatibility Complex  Support, Non-U.S. Gov't  Support, U.S.
       Gov't, P.H.S.  T-Lymphocytes/*IMMUNOLOGY  Virus Replication  JOURNAL
       ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

