       Document 0595
 DOCN  M9640595
 TI    [Clinical manifestations and course of cytomegalovirus colitis in AIDS
       patients]
 DT    9604
 AU    Giezendanner S; Wirth HP; Zala G; Weber R; Flury R; Meyenberger C;
       Abteilung fur Gastroenterologie, Universitatsspital Zurich.
 SO    Schweiz Med Wochenschr. 1995 Dec 16;125(50):2417-22. Unique Identifier :
       AIDSLINE MED/96135388
 AB    The clinical findings and course in 10 HIV-positive patients with
       cytomegalovirus (CMV) colitis were analyzed. Homosexuality was the main
       risk factor for HIV infection. All patients had markedly reduced CD4
       counts (mean 25 x 10(9)/l). Symptoms at presentation were chronic
       diarrhea, weight loss, fever and abdominal pain. One of the patients had
       an abdominal mass in the ileocecal region due to inflammation as the
       leading symptom. Endoscopically the colitis was more often segmental
       than diffuse. In 2 out of 9 patients who underwent colonoscopy, only the
       right hemicolon was affected. Concurrent intestinal infections with up
       to 4 different pathogens were found in 7 patients. 5 patients had
       chorioretinitis as an extraintestinal CMV symptom (2 before, 3 after the
       occurrence of CMV-colitis). In only one patient was there a partial
       response of CMV-colitis to therapy with ganciclovir and foscarnet. Even
       under therapy CMV colitis was complicated in 2 patients by perforation
       and inflammatory stenosis respectively. Both needed surgical treatment.
       Most of the patients died of generalized CMV infection or wasting
       syndrome.
 DE    Adult  Antiviral Agents/THERAPEUTIC USE  AIDS-Related Opportunistic
       Infections/*VIROLOGY  Cohort Studies  Colitis/DIAGNOSIS/*VIROLOGY
       Colonoscopy  Cytomegalovirus/ISOLATION & PURIF  Cytomegalovirus
       Infections/*COMPLICATIONS/DIAGNOSIS/DRUG THERAPY  Cytomegalovirus
       Retinitis/COMPLICATIONS  English Abstract  Foscarnet/THERAPEUTIC USE
       Ganciclovir/THERAPEUTIC USE  Human  HIV Infections/*COMPLICATIONS  Male
       Middle Age  Retrospective Studies  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

