       Document 0604
 DOCN  M9640604
 TI    [Clinical experimentation with HIV vaccines: scientific and ethical
       dilemmas]
 DT    9604
 AU    Lallemant M; Le Coeur S; Harvard School of Public Health, Cancer Biology
       Department,; Boston, MA 02115, USA.
 SO    Pubbl Stn Zool Napoli II. 1995;17(1):151-69. Unique Identifier :
       AIDSLINE MED/96137667
 AB    Developing a vaccine against HIV is one of the greatest challenges the
       scientific community faces today. Several vaccine candidates have
       undergone preliminary safety and immunogenicity studies in humans.
       Research teams are ready to test these vaccines in the field, yet the
       scientific community is divided as to whether efficacy trial should
       begin. This paper addresses the complex scientific and ethical issues
       raised by clinical trials. Considering the pressure to act rapidly to
       solve the crisis, scientists need to hold to the fundamental principles
       that guide decisions in biomedical research: respect for persons,
       beneficence and justice. Because these studies need to enroll a large
       number of subjects, prospective vaccines will need to be tested in
       developing, as well as industrial countries. The international community
       needs to work to ensure that the populations that accept the risk of the
       research receive the full benefit of that research and, that the vaccine
       proven successful, be made accessible and affordable to people in less
       economically developed situation.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY/MORTALITY  Adult  *AIDS
       Vaccines/IMMUNOLOGY  Child  *Clinical Trials  Developed Countries
       Developing Countries  English Abstract  *Ethics, Medical  Female  Human
       HIV-1/IMMUNOLOGY  HIV-2/IMMUNOLOGY  Male  Physician-Patient Relations
       Research  Socioeconomic Factors  World Health Organization  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

