       Document 0605
 DOCN  M9640605
 TI    Strategies of research for a vaccine against AIDS.
 DT    9604
 AU    Essex M; Harvard AIDS Institute, Boston, MA 02115, USA.
 SO    Pubbl Stn Zool Napoli II. 1995;17(1):141-9. Unique Identifier : AIDSLINE
       MED/96137666
 AB    Retroviruses replicate by inserting their proviral DNA into host cell
       chromosomes, usually in cells of the immune system. Nevertheless, an
       efficacious and safe subunit recombinant vaccine has been prepared
       against the feline leukemia retrovirus of cats. Because of high rates of
       morbidity and mortality, particularly in the developing world, the
       development of a vaccine against human immunodeficiency virus type I
       (HIV-I) has become very important. The very high rate of mutation or
       variation of lentiviruses, such as HIV-I, makes a vaccine against this
       virus particularly difficult. Active research must be encouraged to
       design a modified envelope vaccine molecule of gp120 subtype E or C for
       trials in appropriate developing country settings.
 DE    Acquired Immunodeficiency Syndrome/ETIOLOGY/IMMUNOLOGY  Africa  Animal
       Asia  *AIDS Vaccines/IMMUNOLOGY  Cats  Developed Countries  Female
       Human  HIV-1/IMMUNOLOGY  HTLV-I/IMMUNOLOGY  Infant, Newborn
       International Cooperation  Male  Research  United States  Vaccines,
       Synthetic  Viral Vaccines/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

