       Document 0626
 DOCN  M9640626
 TI    Suppression of apoptosis in mammalian cells by NAIP and a related family
       of IAP genes.
 DT    9604
 AU    Liston P; Roy N; Tamai K; Lefebvre C; Baird S; Cherton-Horvat G;
       Farahani R; McLean M; Ikeda JE; MacKenzie A; Korneluk RG; Molecular
       Genetics Research Laboratory, Children's Hospital of; Eastern Ontario,
       Ottawa, Canada.
 SO    Nature. 1996 Jan 25;379(6563):349-53. Unique Identifier : AIDSLINE
       GENBANK/M96581
 AB    Dysregulation of apoptosis can result in inappropriate suppression of
       cell death, as occurs in the development of some cancers, or in failure
       to control the extent of cell death, as is believed to occur in acquired
       immunodeficiency and certain neurodegenerative disorders, such as spinal
       muscular atrophy (SMA). Recently, we isolated a candidate gene, encoding
       neuronal apoptosis inhibitor protein (NAIP), for SMA. This gene is
       homologous to two baculovirus inhibitor of apoptosis proteins (Cp-IAP
       and Op-IAP) and is partly deleted in individuals with type I SMA. A
       second SMA candidate gene encoding survival motor neuron (SMN), which is
       contiguous with the NAIP locus on 5q13.1, was also reported. Here we
       demonstrate a NAIP-mediated inhibition of apoptosis induced by a variety
       of signals, and have identified three additional human complementary
       DNAs and a Drosophila melanogaster sequence that are also homologous to
       the baculovirus IAPs. The four open reading frames (ORFs) possess three
       baculoviral inhibition of apoptosis protein repeat (BIR) domains and a
       carboxy-terminal RING zinc-finger. The human iap genes have a distinct
       but overlapping pattern of expression in fetal and adult tissues. These
       proteins significantly increase the number of known apoptotic
       suppressors.
 DE    Adult  Amino Acid Sequence  Animal  Apoptosis/DRUG
       EFFECTS/GENETICS/*PHYSIOLOGY  Baculoviridae/GENETICS  Base Sequence
       Cell Line  CHO Cells  Drosophila melanogaster/GENETICS  DNA Primers
       DNA, Complementary  Fetus/METABOLISM  Genes, Reiterated  Hamsters  Hela
       Cells  Human  Mice  Molecular Sequence Data  Muscular Atrophy,
       Spinal/GENETICS  Nerve Tissue Proteins/GENETICS/*PHYSIOLOGY  Sequence
       Homology, Amino Acid  Support, Non-U.S. Gov't  Transfection  Tumor
       Necrosis Factor/PHARMACOLOGY  Viral Proteins/GENETICS  Vitamin
       K/PHARMACOLOGY  Zinc Fingers/GENETICS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

