       Document 0628
 DOCN  M9640628
 TI    [Functional activity of T-, B-lymphocytes, and macrophages during
       suppression of expression of the env gene from an endogenous retrovirus
       genome]
 DT    9604
 AU    Gaidul' KV; Chernukhin IV; Khaldoianidi SK; Svinarchuk FP; Vlasov VV;
       Kozlov VA
 SO    Mol Biol (Mosk). 1995 May-Jun;29(3):612-8. Unique Identifier : AIDSLINE
       MED/96163170
 AB    Incubation of murine spleen cells with antisense oligonucleotide
       complementary to initiation site of this gene highly increased RNA
       synthesis relative to the normal T- and B-lymphocytes from spleen. In
       macrophages, inhibition of gene env expression stimulated phagocytosis
       and IL-1 production. Under these conditions, the level of expression of
       proviral envelope transmembrane p15E protein, which in infectious type C
       retroviruses is known to be immunosuppressive, decreased in spleen
       cells. Antisense oligonucleotide stimulatory effect on murine spleen
       cell RNA synthesis is presumably related to the reduced production of
       endogenous p15E.
 DE    Amino Acid Sequence  Animal  B-Lymphocytes/*IMMUNOLOGY  Base Sequence
       Cells, Cultured  English Abstract  *Genes, env
       Interleukin-1/BIOSYNTHESIS  Macrophages/*IMMUNOLOGY  Mice  Mice, Inbred
       CBA  Mice, Inbred C57BL  Mink Cell Focus-Inducing
       Viruses/*GENETICS/IMMUNOLOGY  Molecular Sequence Data
       Oligodeoxyribonucleotides  Phagocytosis/GENETICS  RNA,
       Viral/BIOSYNTHESIS  Spleen/CYTOLOGY/IMMUNOLOGY
       T-Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

