       Document 0632
 DOCN  M9640632
 TI    Characterization of T cell clones from chagasic patients: predominance
       of CD8 surface phenotype in clones from patients with pathology.
 DT    9604
 AU    Cuna WR; Cuna CR; Departamento de Parasitologia, Instituto Boliviano de
       Biologia; de Altura, Facultad de Medicina, La Paz, Bolivia.
 SO    Mem Inst Oswaldo Cruz. 1995 Jul-Aug;90(4):503-6. Unique Identifier :
       AIDSLINE MED/96092422
 AB    Human Chagas' disease, caused by the protozoan Trypanosoma cruzi, is
       associated with pathological processes whose mechanisms are not known.
       To address this question, T cell lines were developed from chronic
       chagasic patients peripheral blood mononuclear cells (PBMC) and cloned.
       These T cell clones (TCC) were analyzed phenotypically with monoclonal
       antibodies by the use of a fluorescence microscope. The surface
       phenotype of the TCC from the asymptomatic patient were predominantly
       CD4 positive (86%). On the contrary, the surface phenotype CD8 was
       predominant in the TCC from the patients suffering from cardiomegaly
       with right bundle branch block (83%), bradycardia with megacolon (75%)
       and bradycardia (75%). Future studies will be developed in order to
       identify the antigens eliciting these T cell subpopulations.
 DE    Animal  Antigens, Protozoan/IMMUNOLOGY  Chagas Disease/*IMMUNOLOGY
       Chronic Disease  Clone Cells  *CD4-CD8 Ratio  Human  Immunophenotyping
       Support, Non-U.S. Gov't  T-Lymphocytes/*IMMUNOLOGY  Trypanosoma
       cruzi/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

