       Document 0664
 DOCN  M9640664
 TI    Thyroid abnormalities in children infected with human immunodeficiency
       virus.
 DT    9604
 AU    Hirschfeld S; Laue L; Cutler GB Jr; Pizzo PA; Pediatric Branch, National
       Cancer Institute, National Institutes; of Health, Bethesda, Maryland
       20892, USA.
 SO    J Pediatr. 1996 Jan;128(1):70-4. Unique Identifier : AIDSLINE
       MED/96144596
 AB    OBJECTIVE: To study thyroid function in children infected with human
       immunodeficiency virus (HIV) and determine whether there are correlates
       of thyroid dysfunction with disease progression. STUDY DESIGN: Total and
       free thyroxine, triiodothyronine, reverse triiodothyronine, thyrotropin,
       and thyroxine binding globulin (TBG) were measured in 167 children with
       HIV infection (age, 1 to 19 years; mean, 9.15 years). SETTING: Pediatric
       Branch, National Cancer Institute. RESULTS: Free thyroxine was at or
       below the lower limit of normal (normal, 1.0 to 1.9 ng/dl) in 18% of the
       children; thyrotropin and TBG levels were above the normal range in 31%
       and 30%, respectively. There was an inverse correlation between CD4+
       cell count and thyrotropin, and between CD4+ cell count and TBG. No
       correlation was found between thyroid function and other disease
       symptoms or medications. CONCLUSION: These findings indicate that
       thyroid abnormalities occur more frequently in children with HIV
       infection than was previously reported, have a different profile from
       the thyroid abnormalities associated with other chronic disease
       conditions, and correlate with disease progression.
 DE    Adolescence  Analysis of Variance  Child  Child, Preschool  CD4
       Lymphocyte Count  Disease Progression  Female  Human  HIV
       Infections/BLOOD/IMMUNOLOGY/*PHYSIOPATHOLOGY  Male  Prevalence
       Regression Analysis  Thyroid Gland/*PHYSIOPATHOLOGY  Thyroid
       Hormones/*BLOOD  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

