       Document 0669
 DOCN  M9640669
 TI    Biological phenotypes of HIV-1 subtypes A and B strains of diverse
       origins.
 DT    9604
 AU    Nkengasong JN; Peeters M; Zhong P; Willems B; Janssens W; Heyndrickx L;
       Fransen K; Ndumbe PM; Gershy-Damet GM; Nys P; et al; Institute of
       Tropical Medicine, Antwerp, Belgium.
 SO    J Med Virol. 1995 Nov;47(3):278-84. Unique Identifier : AIDSLINE
       MED/96129557
 AB    The identification of specific biologic phenotypic traits that can be
       correlated with different HIV-1 genetic subtypes was sought. The genetic
       subtypes were determined by either sequencing (Cameroonian strains, n =
       18) or by the heteroduplex mobility assay (HMA) (Belgian strains, n = 21
       and Ivorian strains, n = 25). Seventeen (81%) of the 21 Belgian isolates
       belonged to subtype B and 4 (17%) were subtype A strains. Subtype A
       variants were predominant in the two African countries studied; 11 (61%)
       of 18 strains from Cameroon and 23 (92%) of 25 strains from the Ivory
       Coast. Of the 64 isolates, 38 (58%) and 19 (29%) belonged to subtypes A
       and B, respectively. No significant difference was observed for
       biological phenotypes (slow/low and rapid/high) of both genetic
       subtypes. In symptomatic individuals, however, a significantly higher
       number of subtype B isolates were of rapid/high phenotype, compared with
       subtype A (5 of 10; 50%) vs. 2 of 22; 9%), respectively; X2 = 6.7, P =
       0.02). The findings suggest that overall HIV-1 isolates belonging to
       genetic subtype B are not distinguishable from subtype A variants on the
       basis of their biological phenotypes. Syncytium-inducing variants were
       less prevalent regardless of the geographic origin of the isolates.
 DE    Base Sequence  Cell Line  DNA Primers  Genotype  Giant Cells/VIROLOGY
       Human  HIV Seropositivity/*VIROLOGY
       HIV-1/*CLASSIFICATION/GENETICS/ISOLATION & PURIF  Molecular Sequence
       Data  Phenotype  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

