       Document 0674
 DOCN  M9640674
 TI    Serum anti-p24 antibody concentration has a predictive value on the
       decrease of CD4 lymphocyte count higher than acid-dissociated p24
       antigen.
 DT    9604
 AU    Morand-Joubert L; Bludau H; Lerable J; Petit JC; Lefrere JJ; Service de
       Bacterio-Virologie, Hopital Saint-Antoine, Paris,; France.
 SO    J Med Virol. 1995 Sep;47(1):87-91. Unique Identifier : AIDSLINE
       MED/96048327
 AB    We studied the prognostic value on the decrease of CD4 lymphocyte count
       of anti-p24 antibody (ab) titer and compared this value with that of
       polyclonal and monoclonal p24 (ag) titer before and after immune complex
       dissociation (ICD); 53 human immunodeficiency virus (HIV)-infected
       patients having CD4+ counts above 400/mm3 when first examined were
       followed up over a 3-year period including at least four visits; HIV
       disease progressors (n = 18) were defined as having CD4+ counts below
       200/mm3 and non-progressors (n = 35) as having CD4+ counts still above
       400/mm3 at the end of follow-up. Sera were collected at each visit and
       assayed for p24 ag with and without ICD and for anti-p24 ab titer. The
       mean anti-p24 ab titer of progressors and of non-progressors at entry
       was significantly different. A threshold of anti-p24 ab titer indicating
       a HIV progression was determined at 1/300. The proportion of individuals
       with an anti-p24 ab titer lower than 1/300 at least once during the
       study period was 34% in non-progressors and 94% in progressors. The
       difference between progressors and non-progressors at entry was
       significant with monoclonal p24 ag without ICD and more significant with
       monoclonal p24 ag after ICD. The marker having the highest predictive
       value was the anti-p24 ab titer, then monoclonal p24 ag with ICD, then
       polyclonal p24 ag with ICD. Anti-p24 ab is an earlier and stronger
       marker of the decrease of CD4 lymphocyte count than p24 ag even after
       ICD.
 DE    Acids  Adult  Antigen-Antibody Complex/IMMUNOLOGY  *CD4 Lymphocyte Count
       Disease Progression  Follow-Up Studies  Human  HIV Antibodies/*BLOOD
       HIV Antigens/*BLOOD  HIV Core Protein p24/*IMMUNOLOGY  HIV
       Infections/*IMMUNOLOGY  Longitudinal Studies  Male  Predictive Value of
       Tests  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

