       Document 0677
 DOCN  M9640677
 TI    Human herpesvirus-6: a survey of presence and distribution of genomic
       sequences in normal brain and neuroglial tumors.
 DT    9604
 AU    Luppi M; Barozzi P; Maiorana A; Marasca R; Trovato R; Fano R;
       Ceccherini-Nelli L; Torelli G; Department of Medical Sciences,
       University of Modena, Italy.
 SO    J Med Virol. 1995 Sep;47(1):105-11. Unique Identifier : AIDSLINE
       MED/96048330
 AB    In an attempt to study the frequency and distribution of human
       herpesvirus-6 (HHV-6) infection both in normal and neoplastic brain
       tissues in vivo, polymerase chain reaction was used to look for HHV-6
       genomes: 1) in samples, obtained at necropsy, from different regions of
       the brain of immunocompetent adult subjects and of patients who died of
       AIDS; 2) in the surgical biopsies of a well-characterized series of
       primary brain tumors of neuroglial origin. HHV-6-specific sequences were
       identified in six of nine brain samples from immunocompetent subjects,
       and in four of seven brain samples from AIDS patients. Viral sequences
       were identified in the specimens derived either from the grey (frontal
       cortex and basal ganglia) or from the periventricular white matter.
       HHV-6 DNA was found only in 6 of the 37 primary brain tumor biopsies
       examined. This study provides for the first time molecular evidence of a
       wide distribution of HHV-6 infection in the brain tissues of a high
       proportion of subjects, both in normal and in impaired immunity. In this
       large series of tumor biopsies the presence of HHV-6 genomic sequences
       is a rare phenomenon, arguing against a major role of this herpesvirus
       in the pathogenesis of primary brain tumors of neuroglial origin in
       immunocompetent subjects.
 DE    Acquired Immunodeficiency Syndrome/PATHOLOGY/VIROLOGY  Adult
       Brain/*VIROLOGY  Brain Neoplasms/PATHOLOGY/*VIROLOGY  DNA,
       Viral/*ANALYSIS  Genome, Viral  Herpesvirus 4, Human/GENETICS/ISOLATION
       & PURIF  Herpesvirus 6, Human/GENETICS/*ISOLATION & PURIF  Human
       Immunocompetence  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

