       Document 0681
 DOCN  M9640681
 TI    CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer
       rapid onset of diabetes in NOD mice in the absence of CD4 cells.
 DT    9604
 AU    Wong FS; Visintin I; Wen L; Flavell RA; Janeway CA Jr; Section of
       Immunobiology, Yale University School of Medicine, New; Haven,
       Connecticut 06510, USA.
 SO    J Exp Med. 1996 Jan 1;183(1):67-76. Unique Identifier : AIDSLINE
       MED/96136749
 AB    T cells play an important role in the pathogenesis of diabetes in the
       nonobese diabetic (NOD) mouse. CD8 cytotoxic T cell lines and clones
       were generated from the lymphocytic infiltrate in the islets of
       Langerhans of young (7-wk-old). NOD mice by growing them on (NOD x
       B6-RIP-B7-1)F1 islets. These cells proliferate specifically to NOD
       islets and kill NOD islets in vitro. The cells are restricted by H-2Kd,
       and all bear T cell antigen receptor encoded by V beta 6. When these CD8
       T cell lines and clones are adoptively transferred to irradiated female
       NOD, young NOD-SCID, and CB17-SCID mice, diabetes occurs very rapidly,
       within 10 d of transfer and without CD4 T cells.
 DE    Amino Acid Sequence  Animal  Antigens, CD80/GENETICS/*IMMUNOLOGY  Base
       Sequence  Clone Cells  Cytokines/BIOSYNTHESIS  CD4-Positive
       T-Lymphocytes/*IMMUNOLOGY  CD8-Positive T-Lymphocytes/*IMMUNOLOGY
       Diabetes Mellitus, Non-Insulin-Dependent/*IMMUNOLOGY  Female
       Immunohistochemistry  Immunotherapy, Adoptive  Insulin/GENETICS  Islets
       of Langerhans/*IMMUNOLOGY  Lymphocyte Transformation  Membrane
       Glycoproteins/BIOSYNTHESIS  Mice  Mice, Inbred BALB C  Mice, Inbred
       C57BL  Mice, Inbred NOD  Mice, SCID  Molecular Sequence Data
       Pancreas/ANATOMY & HISTOLOGY  Promoter Regions (Genetics)/GENETICS
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

