       Document 0695
 DOCN  M9640695
 TI    Mouse microglial cell lines differing in constitutive and
       interferon-gamma-inducible antigen-presenting activities for naive and
       memory CD4+ and CD8+ T cells.
 DT    9604
 AU    Walker WS; Gatewood J; Olivas E; Askew D; Havenith CE; Department of
       Immunology, St. Jude Children's Research Hospital,; Memphis, TN 3810,
       USA.
 SO    J Neuroimmunol. 1995 Dec 31;63(2):163-74. Unique Identifier : AIDSLINE
       MED/96133576
 AB    We developed a panel of non-virus transformed cell lines derived from
       individual microglial precursors residing in the brains of normal mice.
       These colony stimulating factor-1-dependent cell lines are B7-1+ (CD80),
       Mac-1+, Mac-2+, Mac-3+, CD45+, MHC class I+, colony stimulating factor-1
       receptor+, and they ingest antibody-coated particles. However, the cell
       lines differ in their expression of B7-2 (CD86), F4/80, Ly-6C and MHC
       class II molecules. They also differ in their ability to constitutively
       process and present antigens to naive CD4+ and CD8+ T cells, memory CD4+
       and CD8+, and in the manner by which interferon gamma modulates their
       antigen-presenting activities. These cell lines should be valuable as
       models for studies on the immunobiology of the microglia.
 DE    Adjuvants, Immunologic  Animal  Antigen Presentation/*IMMUNOLOGY
       Antigens, Viral/IMMUNOLOGY  Cell Line/CYTOLOGY/IMMUNOLOGY  CD4-Positive
       T-Lymphocytes/*IMMUNOLOGY  CD8-Positive T-Lymphocytes/*IMMUNOLOGY
       Hemocyanin  Hybridomas  Immunologic Memory/IMMUNOLOGY  Interferon Type
       II/*IMMUNOLOGY  Isoantigens/IMMUNOLOGY  Mice  Mice, Inbred C3H  Mice,
       Inbred C57BL  Mice, Transgenic  Microglia/CHEMISTRY/*CYTOLOGY/IMMUNOLOGY
       Phagocytosis/IMMUNOLOGY  Phenotype  Support, Non-U.S. Gov't  Support,
       U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

