       Document 0696
 DOCN  M9640696
 TI    The immune profile of multiple sclerosis: T-lymphocyte effects
       predominate over all other factors in cyclophosphamide-treated patients.
 DT    9604
 AU    Strauss K; Hulstaert F; Deneys V; Mazzon AM; Hannet I; De Bruyere M;
       Reichert T; Sindic CJ; Becton Dickinson Immunocytometry Systems,
       Erembodegem-Aalst,; Belgium.
 SO    J Neuroimmunol. 1995 Dec 31;63(2):133-42. Unique Identifier : AIDSLINE
       MED/96133572
 AB    It is widely believed that multiple sclerosis is a T-cell mediated
       autoimmune disease associated with abnormalities in immunoregulation.
       This large, prospective study evaluated the lymphocyte immunophenotypic
       profile of 246 MS patients, divided clinically into a
       remitting/relapsing group (n = 176) and a progressive group (n = 70),
       and compared their results to those of 117 healthy controls. All
       patients were found to have significantly elevated percentage and
       absolute numbers of IL2R+CD3+ cells as well as depressed percentages of
       CD45RA+CD4+ cells. However, when the factor of treatment with
       cyclophosphamide (CY) versus no treatment or treatment with other agents
       was used to group patients, dramatic declines in both percentages and
       absolute numbers of CD45RA+CD4+ cells were discovered. These declines
       were associated specifically with CY and and could be explained by this
       factor independent of the clinical state of the patient. The effects
       were seen in patients undergoing current treatment or in those exposed
       to CY in the near or remote past. These findings highlight the
       confounding effect of specific treatments on the immune profile of MS
       patients groups and suggest that there may be important implications for
       cellular function and clinical outcome in these and other patient
       groups.
 DE    Adult  Age Factors  Antigens, CD3/METABOLISM  Antigens, CD45/METABOLISM
       Cyclophosphamide/ADMINISTRATION & DOSAGE  CD4 Lymphocyte Count  Disease
       Progression  Female  Human  Immunophenotyping  Immunosuppression
       Interleukin-2/METABOLISM  Linear Models  Lymphocyte Subsets/METABOLISM
       Male  Multiple Sclerosis/DRUG THERAPY/*IMMUNOLOGY  Prospective Studies
       Recurrence  Sex Factors  T-Lymphocytes/CHEMISTRY/*IMMUNOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

