       Document 0703
 DOCN  M9640703
 TI    Strenuous exercise and immunological changes: a multiple-time-point
       analysis of leukocyte subsets, CD4/CD8 ratio, immunoglobulin production
       and NK cell response.
 DT    9604
 AU    Shek PN; Sabiston BH; Buguet A; Radomski MW; Defence and Civil Institute
       of Environmental Medicine, North; York, Ontario, Canada.
 SO    Int J Sports Med. 1995 Oct;16(7):466-74. Unique Identifier : AIDSLINE
       MED/96128797
 AB    This study was designed to examine the impact of exhaustive endurance
       exercise on a number of immune parameters of physically fit male
       subjects (VO2max 66.5 +/- 5.3 ml/min/kg) who performed treadmill
       exercise at 65% of their VO2max for 120 min. Serial blood samples were
       taken before, during and after exercise and changes in leukocyte and
       lymphocyte subset concentrations; immunoglobulin production in vitro;
       and natural killer (NK) cell response were measured. The exercise
       regimen was found to induce the well-known phenomenon of leukocytosis
       which consisted primarily of a granulocytosis and lymphocytosis. Among
       the lymphocyte subsets, peripheral pan T cells (CD3+) as well as helper
       (CD4+) and suppressor (CD8+) T cells were found to be elevated. A
       relatively smaller increase in CD4+ than CD8+ cells resulted in
       depressed CD4/CD8 ratios throughout the exercise period. After exercise,
       T cells declined progressively and, 2 h post-exercise, were less than
       60% of their pre-exercise level. In contrast, the CD4/CD8 ratio
       demonstrated a progressive increase, thus representing a reversal in the
       pattern observed during exercise and a trend towards an elevated ratio
       during recovery. B cells (CD19+) were relatively unaffected by exercise,
       although IgM production by pokeweed mitogen-stimulated lymphocytes
       obtained from blood samples after 120 min of exercise was significantly
       depressed. NK cells were affected dramatically by exercise. Both CD16+
       cell numbers and NK cytotoxicity were increased during exercise,
       followed by a persistent depression in the post-exercise period. The
       strenuous exercise induced profound effect on NK cells as evidenced by a
       40% depression of the NK cell count for as long as 7 days after the
       cessation of exercise. Our results provide direct kinetic evidence
       demonstrating that exhaustive exertion alters both lymphocyte
       distribution pattern and effector function, suggestive of possible
       exercise-induced immune compromise, particularly in the post-exercise
       recovery period.
 DE    Adult  *CD4-CD8 Ratio  Exertion/*PHYSIOLOGY  Human
       Immunoglobulins/*METABOLISM  Killer Cells, Natural/*IMMUNOLOGY
       Leukocyte Count  Lymphocyte Count  *Lymphocyte Subsets  Male  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

