       Document 0708
 DOCN  M9640708
 TI    Intestinal absorptive capacity, intestinal permeability and jejunal
       histology in HIV and their relation to diarrhoea.
 DT    9604
 AU    Keating J; Bjarnason I; Somasundaram S; Macpherson A; Francis N; Price
       AB; Sharpstone D; Smithson J; Menzies IS; Gazzard BG; Department of
       Medicine, Chelsea and Westminster Hospital, London.
 SO    Gut. 1995 Nov;37(5):623-9. Unique Identifier : AIDSLINE MED/96148575
 AB    Intestinal function is poorly defined in patients with HIV infection.
       Absorptive capacity and intestinal permeability were assessed using
       3-O-methyl-D-glucose, D-xylose, L-rhamnose, and lactulose in 88 HIV
       infected patients and the findings were correlated with the degree of
       immunosuppression (CD4 counts), diarrhoea, wasting, intestinal pathogen
       status, and histomorphometric analysis of jejunal biopsy samples.
       Malabsorption of 3-O-methyl-D-glucose and D-xylose was prevalent in all
       groups of patients with AIDS but not in asymptomatic, well patients with
       HIV. Malabsorption correlated significantly (r = 0.34-0.56, p < 0.005)
       with the degree of immune suppression and with body mass index.
       Increased intestinal permeability was found in all subgroups of
       patients. The changes in absorption-permeability were of comparable
       severity to those found in patients with untreated coeliac disease.
       Jejunal histology, however, showed only mild changes in the villus
       height/crypt depth ratio as compared with subtotal villus atrophy in
       coeliac disease. Malabsorption and increased intestinal permeability are
       common in AIDS patients. Malabsorption, which has nutritional
       implications, relates more to immune suppression than jejunal
       morphological changes.
 DE    Adult  Body Mass Index  Celiac Disease/PATHOLOGY/PHYSIOPATHOLOGY
       Comparative Study  CD4 Lymphocyte Count  Diarrhea/*ETIOLOGY/PATHOLOGY
       Female  Human  HIV Infections/COMPLICATIONS/PATHOLOGY/*PHYSIOPATHOLOGY
       *Intestinal Absorption  Jejunum/PATHOLOGY/PHYSIOPATHOLOGY  Male  Middle
       Age  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

