       Document 0714
 DOCN  M9640714
 TI    Survival differences in Austrian patients with the acquired
       immunodeficiency syndrome.
 DT    9604
 AU    Zangerle R; Reibnegger G; Klein JP; Department of Dermatology and
       Venerology, University of; Innsbruck, Austria.
 SO    Eur J Epidemiol. 1995 Oct;11(5):519-26. Unique Identifier : AIDSLINE
       MED/96139645
 AB    We investigated the association of clinical and demographic factors on
       survival of the 901 AIDS cases diagnosed until 31 December 1992 and
       reported to the Austrian Health Authorities up to 20 January 1994. The
       overall estimated median survival of patients with AIDS increased
       substantially from 8 months in 1987 to 16 months in 1988, although this
       increase was not significant by the log-rank test. However, the
       differences in hazard rates were larger at the beginning of the survival
       curve: between 1987 and 1988 the proportion surviving at 1 year
       increased from 41 to 62%, compared to an increase of the proportion
       surviving at 2 years from 30 to 35% (Breslow test, p value 0.008). AIDS
       patients diagnosed between 1988 and 1992 (n = 755) were analyzed in more
       detail. Multivariate survival analysis revealed a shorter survival for
       those with residence in Eastern Austria, recipients of blood products,
       individuals with unknown transmission risk, those presenting with two
       AIDS indicator diseases and those with higher age at AIDS diagnosis.
       Candidal esophagitis as AIDS indicator disease was associated with
       longer survival. One hundred eighty-eight of the 755 AIDS patients
       (24.9%) died within the first 3 months after diagnosis of AIDS. We
       conclude that the survival time for AIDS patients has improved
       considerably after 1987, but survival is still very poor. Several
       factors have been shown to predict survival of patients with AIDS in
       Austria. Death within the first 3 months after the diagnosis of AIDS
       occurred at a relatively high frequency in Austrian AIDS patients. This
       may be caused by difficulties in the use of health care facilities or by
       the lack of awareness of HIV infection before diagnosis of AIDS either
       by patient or care provider.
 DE    Acquired Immunodeficiency Syndrome/*MORTALITY/TRANSMISSION  Adolescence
       Adult  Age Factors  Aged  Austria/EPIDEMIOLOGY  AIDS-Related
       Opportunistic Infections/MORTALITY  Blood Transfusion/STATISTICS & NUMER
       DATA  Candidiasis/MORTALITY  Comparative Study  Disease Notification
       Esophagitis/MICROBIOLOGY/MORTALITY  Female  Forecasting  Human  HIV
       Infections/MORTALITY  Logistic Models  Male  Middle Age  Multivariate
       Analysis  Proportional Hazards Models  Residence Characteristics  Risk
       Factors  Survival Analysis  Survival Rate  Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

