       Document 0718
 DOCN  M9640718
 TI    Cervical intraepithelial neoplasia and human papillomavirus related
       lesions of the genital tract in HIV positive and negative women.
 DT    9604
 AU    Branca M; Delfino A; Rossi E; Giacomini G; Leoncini L; Riti MG; Morosini
       PL; Laboratory of Epidemiology and Biostatistic, National Health;
       Institute, Rome, Italy.
 SO    Eur J Gynaecol Oncol. 1995;16(5):410-7. Unique Identifier : AIDSLINE
       MED/96076311
 AB    Two hundred and twenty one women at high risk for HIV (intravenous drug
       users and/or those with infected partners) were investigated, through a
       self-filled questionnaire and gynaecological examination, to define the
       relationship between genital Human Papilloma Virus (HPV) infections,
       preneoplastic cervical intraepithelial lesions (CIN) and behavioural
       risk factors. In the 121 HIV positive women, 58 (47%) had HPV lesions at
       colposcopic and/or cytologic examination and, out of these 58, 23 (40%)
       had CIN 1, CIN 2 or CIN 3. Six out of the 16 cases with CIN 1 and CIN 2
       (37%) followed-up showed a rapid progression of the lesion to CIN 3; in
       3 women the interval was 6 months, in the other 3 about 12 months. Only
       5 (7%) of the remaining 66 women without HPV lesions had a CIN lesion,
       with an obviously significant difference on comparison with HPV positive
       subjects. Sixty two women out of the 121 (52%) had a previous diagnosis
       of condylomata. In the 100 HIV negative women, 23 (23%) had HPV lesions
       and, among these 23, 6 (26%) had CIN 1, CIN 2 or CIN 3; 1 of them had
       rapid progression from CIN 1 to CIN 3 within a year. Only 5 (3%) without
       HPV infection showed any kind of CIN. 33 women out of 100 (33%) had a
       previous clinical history of condylomata. Our findings strongly suggest
       that HIV infection is associated with HPV lesions and that cervical
       cytological abnormalities develop in this situation. There is a need for
       short interval cytological and colposcopic follow-up for women at high
       risk of HIV infection.
 DE    Adult  Cervical Intraepithelial Neoplasia/*COMPLICATIONS/EPIDEMIOLOGY/
       VIROLOGY  Cervix Neoplasms/*COMPLICATIONS/EPIDEMIOLOGY/VIROLOGY  Female
       Human  HIV Seropositivity/*COMPLICATIONS/EPIDEMIOLOGY  Logistic Models
       Papillomavirus, Human/*ISOLATION & PURIF  Papovaviridae
       Infections/*COMPLICATIONS/EPIDEMIOLOGY  Prevalence  Risk Factors  Tumor
       Virus Infections/*COMPLICATIONS/EPIDEMIOLOGY  Vaginal Smears  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

