       Document 0723
 DOCN  M9640723
 TI    Effect of injection of anti-CD4 and anti-CD8 monoclonal antibodies on
       the development of experimental systemic lupus erythematosus in mice.
 DT    9604
 AU    Ruiz PJ; Zinger H; Mozes E; Department of Chemical Immunology, Weizmann
       Institute of Science,; Rehovot, Israel.
 SO    Cell Immunol. 1996 Jan 10;167(1):30-7. Unique Identifier : AIDSLINE
       MED/96139348
 AB    Induction of an experimental disease resembling systemic lupus
       erythematosus (SLE) has been achieved in mice by immunization with a
       human monoclonal anti-DNA antibody, bearing a common idiotype,
       designated 16/6 Id. In the present study we used anti-CD4 and anti-CD8
       antibodies to modulate the induction and development of the experimental
       disease. Thus, depletion of CD4+ T cells prior to the immunization with
       the 16/6 inhibited the induction of experimental SLE. In contrast,
       injection of anti-CD4 antibodies to mice that were already immunized
       with the 16/6 Id did not prevent the development of the disease.
       Furthermore, administration of anti-CD8 antibodies either before or
       after priming with the 16/6 Id increased the serological and clinical
       manifestations of the disease. These results demonstrate the pathogenic
       role of CD4+ and CD8+ T cells in the induction and development of the
       experimental SLE.
 DE    Animal  Antibodies, Monoclonal/*IMMUNOLOGY  CD4-Positive
       T-Lymphocytes/*PHYSIOLOGY  CD8-Positive T-Lymphocytes/*PHYSIOLOGY  Human
       Immunization  Lupus Erythematosus, Systemic/*ETIOLOGY  Lymphocyte
       Depletion  Mice  Mice, Inbred C3H  Rats  Support, Non-U.S. Gov't
       Support, U.S. Gov't, Non-P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

