       Document 0732
 DOCN  M9640732
 TI    Adenosine deaminase isoenzyme levels in patients with human T-cell
       lymphotropic virus type 1 and human immunodeficiency virus type 1
       infections.
 DT    9604
 AU    Tsuboi I; Sagawa K; Shichijo S; Yokoyama MM; Ou DW; Wiederhold MD;
       Department of Immunology, Kurume University School of Medicine,; Japan.
 SO    Clin Diagn Lab Immunol. 1995 Sep;2(5):626-30. Unique Identifier :
       AIDSLINE MED/96089403
 AB    In serum, the enzyme adenosine deaminase (ADA) is known to be divided
       into two isoenzymes, ADA1 and ADA2, which have different molecular
       weights and kinetic properties. The present study investigated ADA
       isoenzyme levels in the sera of patients infected with retroviruses
       associated with adult T-cell leukemia (ATL), human T-cell lymphotropic
       virus type 1 (HTLV-1)-associated myelopathy (HAM), and AIDS, ADA
       isoenzyme activities were found to be significantly (P < 0.001) higher
       in the sera of patients with ATL, HAM, and AIDS than in the sera of
       healthy controls. In the case of the ADA subtypes in the sera of
       patients with ATL, ADA1 activity was significantly (P < 0.001) elevated
       in patients with the acute and lymphoma types of ATL compared with that
       in patients with the chronic and smoldering types of ATL. ADA2 activity
       was significantly elevated in the sera of patients with the acute,
       lymphoma, and chronic types of ATL (P < 0.001) compared with that in
       patients with smoldering ATL and HTLV-1 carriers. In the case of
       patients with human immunodeficiency virus type 1 (HIV-1) infection,
       ADA1 and ADA2 activities in the sera of patients with AIDS and HIV-1
       antibody-positive individuals were significantly (P < 0.001) higher than
       those in the sera of HIV-1 antibody-negative individuals. A significant
       elevation in ADA2 activity was also seen in the sera of AIDS patients (P
       < 0.01) compared with that in the sera of HIV-1 antibody-positive
       individuals.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Acquired Immunodeficiency Syndrome/BLOOD/*ENZYMOLOGY  Adenosine
       Deaminase/*BLOOD  Adult  Aged  Aged, 80 and over  Cell Line  Enzyme
       Activation  Female  Human  HIV-1/ENZYMOLOGY  HTLV-I
       Infections/BLOOD/*ENZYMOLOGY  Isoenzymes/*BLOOD  Male  Middle Age
       Support, Non-U.S. Gov't  T-Lymphocytes/ENZYMOLOGY/VIROLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

