       Document 0738
 DOCN  M9640738
 TI    Influence of HIV epidemic on the incidence of Kaposi's sarcoma in
       Zambian children.
 DT    9604
 AU    Athale UH; Patil PS; Chintu C; Elem B; Department of Paediatrics and
       Child Health, University Teaching; Hospital, School of Medicine,
       University of Zambia, Lusaka,; Zambia.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):96-100.
       Unique Identifier : AIDSLINE MED/96142207
 AB    Acquired immunodeficiency syndrome-associated Kaposi's sarcoma (KS) is
       well documented in adults. However, very little information is available
       about KS in the pediatric age group. A retrospectively study was
       undertaken at the University Teaching Hospital (UTH), Lusaka, Zambia, to
       define the incidence and clinical profile of KS in Zambian children over
       the last 13 years and to determine the influence, if any, of the current
       human immunodeficiency virus (HIV) epidemic on the pattern of pediatric
       KS. All the histopathological records from 1980 to 1992 were reviewed
       and all cases of KS along with the total number of malignancies, both in
       children and adults, were analyzed. Along with this, 17 of 23 case files
       of pediatric KS patients treated at the UTH since 1984 were retrieved
       and clinical details recorded. Of a total of 915 cases of KS, 85 (9.25%)
       were in children < 14 years of age. The age ranged from 7 months to 14
       years, with an average of 5.62 years; the male/female ratio was 1.76:1.
       A significant increase in the incidence of pediatric KS has been
       recorded since 1987 (p < 0.001). This coincides with the advent of the
       HIV epidemic in the country. The disease was aggressive and fulminant in
       pediatric patients. More than 80% HIV seropositivity was detected.
       Children with blood transfusion-related HIV infection had cutaneous or
       lymphocutaneous disease, indicating that the mode of acquisition of HIV
       infection may influence the clinical appearance of KS. Thus,
       HIV-associated KS in children is becoming a common entity in Zambia. An
       urgent prospective epidemiologic study is needed to address this problem
       in HIV-affected regions.
 DE    Adolescence  Age Distribution  Child  Child, Preschool  *Disease
       Outbreaks  Female  Human  HIV Infections/COMPLICATIONS/*EPIDEMIOLOGY
       HIV Seropositivity/EPIDEMIOLOGY  *HIV-1  Incidence  Infant  Male
       Retrospective Studies  Sarcoma, Kaposi's/COMPLICATIONS/*EPIDEMIOLOGY
       Sex Distribution  Zambia/EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

