       Document 0739
 DOCN  M9640739
 TI    HIV/HTLV-I coinfection and clinical grade at diagnosis.
 DT    9604
 AU    Chavance M; Neisson-Vernant C; Quist D; Monplaisir N; Armengaud B; Chout
       R; INSERM U169, Recherches en Epidemiologie, Villejuif, France.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):91-5. Unique
       Identifier : AIDSLINE MED/96142206
 AB    A total of 963 HIV-infected patients have been identified or followed up
       in Martinique since 1985. Medical files were used to retrieve
       information about age, sex, circumstances of diagnosis, HTLV-I status,
       and HIV clinical grade at first examination according to CDC criteria
       from 1987. Complete information was available for 774 patients. At the
       first clinical examination, the clinical grade of 65 coinfected patients
       was more severe than that of the monoinfected patients (GIV versus GII,
       OR = 2.60, p < 0.01), but after adjustment for age and sex, this odds
       ratio was reduced 1.57. Although this study cannot invalidate the
       hypothesis of a faster progression toward AIDS of coinfected than of
       monoinfected patients, it shows that one or several other mechanisms
       contribute to the different grades of severity at the first clinical
       examination observed between these two categories of patients. We
       believe that HTLV-I infection acquired during adulthood is a marker of
       high-risk behavior and that it might be associated with early or
       multiple HIV infections.
 DE    Adult  Comparative Study  Confounding Factors (Epidemiology)
       Cross-Sectional Studies  Enzyme-Linked Immunosorbent Assay  Female
       Human  HIV Antibodies/ANALYSIS  HIV
       Infections/*COMPLICATIONS/EPIDEMIOLOGY/PATHOLOGY  *HIV-1/IMMUNOLOGY
       HTLV-BLV Antibodies/ANALYSIS  *HTLV-I/IMMUNOLOGY  HTLV-I
       Infections/*COMPLICATIONS/EPIDEMIOLOGY/PATHOLOGY  HTLV-II/IMMUNOLOGY
       Male  Martinique/EPIDEMIOLOGY  Middle Age  Odds Ratio  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

