       Document 0741
 DOCN  M9640741
 TI    Incidence proportion of and risk factors for AIDS patients diagnosed
       with HIV dementia, central nervous system toxoplasmosis, and
       cryptococcal meningitis.
 DT    9604
 AU    Wang F; So Y; Vittinghoff E; Malani H; Reingold A; Lewis E; Giordano J;
       Janssen R; School of Public Health, University of California/Berkeley,
       USA.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):75-82.
       Unique Identifier : AIDSLINE MED/96142204
 AB    We undertook this study to determine the incidence proportion of and
       risk factors for AIDS patients diagnosed with human immunodeficiency
       virus (HIV) dementia, central nervous system (CNS) toxoplasmosis, and
       cryptococcal meningitis. A historical cohort of 487 consecutive
       inpatients with AIDS treated by San Francisco General Hospital inpatient
       and outpatient services entered the study. We abstracted all available
       records for demographic information, diagnoses, and dates of death and
       estimated the incidence proportion of AIDS patients diagnosed with major
       CNS complications using the Kaplan-Meier method. We used the Cox
       proportional hazards model to analyze the effect of demographic factors
       on the hazard (risk per unit time) of diagnosis with these CNS
       conditions. The estimated incidence proportion of patients diagnosed
       with HIV dementia within 1 and 2 years of AIDS diagnosis increased from
       0.10 to 0.18. Corresponding proportions were 0.10 and 0.19 for CNS
       toxoplasmosis and 0.10 and 0.14 for cryptococcal meningitis. Only HIV
       dementia was independently associated with increasing age at AIDS
       diagnosis (relative hazard [RH] of 2.75 for ages 41-50 [95% confidence
       interval, 1.08-6.98]; RH of 4.73 for ages > 50 [95% confidence interval,
       1.41-15.87]) and with injection drug use (RH of 2.03; 95% confidence
       interval, 1.19-3.47). HIV dementia, CNS toxoplasmosis, and cryptococcal
       meningitis are about equally common complications in patients with AIDS,
       but only HIV dementia is associated with increasing age at AIDS
       diagnosis and injection drug use.
 DE    Adult  Aged  AIDS Dementia Complex/COMPLICATIONS/*EPIDEMIOLOGY
       AIDS-Related Opportunistic Infections/COMPLICATIONS/*EPIDEMIOLOGY
       Cohort Studies  Female  Human  Incidence  Male  Meningitis,
       Cryptococcal/COMPLICATIONS/*EPIDEMIOLOGY  Middle Age  Multivariate
       Analysis  Proportional Hazards Models  Risk Factors  San
       Francisco/EPIDEMIOLOGY  Support, Non-U.S. Gov't  Toxoplasmosis,
       Cerebral/COMPLICATIONS/*EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

