       Document 0742
 DOCN  M9640742
 TI    Changes in markers of disease progression in HIV-1 seroconverters: a
       comparison between cohorts of injecting drug users and homosexual men.
 DT    9604
 AU    Galai N; Vlahov D; Margolick JB; Chen K; Graham NM; Munoz A; Department
       of Epidemiology, Johns Hopkins School of Hygiene and; Public Health,
       Baltimore, Maryland 21205, USA.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):66-74.
       Unique Identifier : AIDSLINE MED/96142203
 AB    Comparisons of human immunodeficiency virus (HIV) disease progression
       between risk groups are difficult primarily because of the long
       incubation period of acquired immune deficiency syndrome (AIDS) and
       unknown times of infection. This is believed to be the first study that
       directly compared changes in T-lymphocyte subsets following HIV-1
       seroconversion between cohorts of predominantly black injecting drug
       users and predominantly white homosexual men. Longitudinal trends of CD4
       and CD8 percentages of total lymphocytes during 4 years were modeled as
       piecewise linear functions with a two-parameter correlation structure to
       accommodate within-person repeated observations. Prior to seroconversion
       the 151 injecting drug users started with similar CD4% and CD8% levels
       compared with the 99 homosexual men. Following seroconversion, larger
       changes were observed overall in the homosexual men compared with the
       injecting drug users for both markers (p < or = 0.001). The major
       discrepancies, however, were limited to the first 2 years. Subsequently,
       the CD4% levels of the two cohorts converged and then declined at
       similar rates. These comparative analyses of HIV seroconverters in
       homosexual men and injecting drug users suggest that risk group has only
       a minor effect on the initial course of HIV infection.
 DE    Adult  Biological Markers  Cohort Studies  Comparative Study  CD4-CD8
       Ratio  CD4-Positive T-Lymphocytes/IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY  Disease Progression  Female  Follow-Up Studies
       *Homosexuality, Male  Human  HIV Infections/IMMUNOLOGY/*PHYSIOPATHOLOGY
       HIV Seropositivity/IMMUNOLOGY/*PHYSIOPATHOLOGY  *HIV-1  Male  Substance
       Abuse, Intravenous/IMMUNOLOGY/*PHYSIOPATHOLOGY  Support, U.S. Gov't,
       P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

