       Document 0758
 DOCN  M9640758
 TI    Abnormalities of measles antibody response in human immunodeficiency
       virus type 1 (HIV-1) infection.
 DT    9604
 AU    Brunell PA; Vimal V; Sandu M; Courville TM; Daar E; Israele V; Ahmanson
       Pediatric Center, Department of Medicine, Cedars-Sinai; Medical Center,
       Los Angeles, California 90048, USA.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15;10(5):540-8.
       Unique Identifier : AIDSLINE MED/96142216
 AB    The finding that severe measles occurs in immunized as well as
       nonimmunized human immunodeficiency virus (HIV)-infected individuals
       suggests that both immunologic memory and the initial response to
       measles may be impaired by HIV infection. That the initial response is
       affected was supported by the finding that post-measles immunization
       titers of HIV-infected babies were significantly lower (p = 0.01) than
       those of normal babies. Poor immunologic memory was evidenced in
       HIV-infected children by lower titers than in normal children (p <
       0.001) and by a continuing decline in measles antibody that was not
       arrested by reimmunization. Impaired memory appeared to be associated
       with defective avidity maturation. HIV-infected babies and infants or
       children had a significantly lower avidity index (AI) than age-matched
       normal children (p < 0.01). HIV-infected adults, who were infected with
       HIV following infection with measles, did not have AI values
       significantly different from normal adults (p = 0.18) but had
       significantly greater values than did HIV-infected babies and children
       (p < 0.01). Thus, in contrast to infants and children who were infected
       with HIV before measles immunization, the adult immune response to
       measles was less affected.
 DE    Adult  Antibodies, Viral/*BIOSYNTHESIS  Antibody Affinity  Child  Child,
       Preschool  CD4 Lymphocyte Count  Enzyme-Linked Immunosorbent Assay
       Human  HIV Infections/*COMPLICATIONS  *HIV-1  Immunization
       Immunization, Secondary  Immunologic Memory  Infant
       Measles/*IMMUNOLOGY/PREVENTION & CONTROL  Measles Vaccine/ADMINISTRATION
       & DOSAGE/IMMUNOLOGY  Measles Virus/*IMMUNOLOGY  Mumps
       Vaccine/ADMINISTRATION & DOSAGE/IMMUNOLOGY  Rubella
       Vaccine/ADMINISTRATION & DOSAGE/IMMUNOLOGY  Support, U.S. Gov't, P.H.S.
       Vaccines, Combined/ADMINISTRATION & DOSAGE/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

