       Document 0770
 DOCN  M9640770
 TI    Molecular biological bases of resistance to HIV/AIDS (the hypothesis
       with elements of the theory).
 DT    9604
 AU    Skripal IG; D. K. Zabolotny Institute of Microbiology and Virology,
       National; Academy of Sciences of Ukraine, Kiev.
 SO    Mikrobiol Z. 1995 Jul-Aug;57(4):89-105. Unique Identifier : AIDSLINE
       MED/96099084
 AB    Proceeding from the structure and function of the shell glycoprotein
       gp120 of the human immunodeficiency virus (HIV) and receptor
       glycoprotein CD4 on target cells for this virus, the author assumes that
       in nature there is genetically determined human resistance to the HIV
       infection and AIDS. This resistance manifests itself indirectly via
       products of the glycosylation system and via the composition and order
       of amino-acid residues in receptor CD4 sites responsible for interaction
       between the receptor and glycoprotein gp120. The author thinks that
       people in whom the glycosylation system determines either B(III) or
       AB(IV) blood groups are potential subjects of the HIV infection. But
       development of AIDS necessitates some conditions more, one of them is
       susceptibility of the human organism to be infected with mollicute
       Mycoplasma fermentans. This mycoplasma is able to recognize terminal
       NeuAc alpha 2-3 Gal in the composition of oligosaccharides of gp120,
       which permits it to adhere HIV virions on itself and then to transport
       them directly to the cells expressing receptor CD4 and having
       oligosaccharides of the same terminal structure. Oligosaccharides of
       glycocalyx of the mycoplasma protect it from the action of the human
       immune system and the mycoplasma, having transported HIV virions to
       target cells combines with membranes of the latter, stimulates formation
       by them of interleukin-1 and tumour necrosis factor, the known effectors
       of this virus reproduction. On the basis of all these factors the author
       identifies four types of human resistance to HIV/AIDS.
 DE    Acquired Immunodeficiency Syndrome/ETHNOLOGY/GENETICS/*IMMUNOLOGY  Amino
       Acid Sequence  Antigens, CD4/GENETICS/IMMUNOLOGY  Blood
       Groups/GENETICS/IMMUNOLOGY  Human  HIV Envelope Protein
       gp120/GENETICS/IMMUNOLOGY  HIV Infections/ETHNOLOGY/GENETICS/*IMMUNOLOGY
       HIV-1/GENETICS/*IMMUNOLOGY  Molecular Sequence Data  Mycoplasma
       fermentans/GENETICS/IMMUNOLOGY  Mycoplasma
       Infections/GENETICS/IMMUNOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW,
       TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

