       Document 0771
 DOCN  M9640771
 TI    [Carbohydrate receptors for Mycoplasma fermentans adhesion on human
       epithelial tissues]
 DT    9604
 AU    Skrypal' IH; Tokovenko IP; Malynovs'ka LP
 SO    Mikrobiol Z. 1995 Jul-Aug;57(4):17-22. Unique Identifier : AIDSLINE
       MED/96099077
 AB    It has been stated that two terminal carbohydrates from polysaccharide
       complexes which are on the surface of human epithelial tissues, namely,
       alpha-D-glucose and N-acetylneuramino acid bound with subterminal
       galactose via alpha 2-->3-bond (NeuAc alpha 2-->3 Gal), may serve
       receptors for Mycoplasma fermentans adhesion on human epithelial cells.
       M. fermentans shows high selectivity to these receptors, though very low
       affinity. The latter, probably, explains why this mycoplasma is able to
       infect only the limited number of peoples. In the authors' opinion
       people with the lower content of glucose in urine, as well as those who
       suffer from diseases associated with hypothalamo-hypophyseal
       insufficiency are subjected to infection with M. fermentans. People with
       normal (3.33-5.55 mM) and elevated alpha-D-glucose content in blood and
       in urine are not susceptible to this mycoplasma. Results of the research
       carried have shown that alpha-D-glucose solutions of definite
       concentration may be used to eliminate M. fermentans from the urogenital
       tract of people who have it. The ability of M. fermentans to
       discriminate terminal structure of NeuAc alpha 2-->3 Gal provides it
       with the possibility to adhere human immunodeficiency virus virions on
       its cells as glycoprotein (gp120) of that virus has among its own
       oligosaccharides certain glycopolymers of the similar terminal
       structure. Then M. fermentans transports the virions directly to target
       cells for this virus. The target cells express receptor CD4 glycolized
       by oligosaccharides of the mentioned terminal structure. It provides
       adhesion of the mycoplasma on the receptor.
 DE    Bacterial Adhesion/*PHYSIOLOGY  English Abstract
       Epithelium/METABOLISM/MICROBIOLOGY  Hemagglutination Tests  Human
       HIV-1/METABOLISM  Mycoplasma fermentans/METABOLISM/*PATHOGENICITY
       Oligosaccharides/METABOLISM  Polysaccharides, Bacterial/*METABOLISM
       Receptors, Immunologic/*METABOLISM  Receptors, Virus/METABOLISM
       Urogenital System/*METABOLISM/MICROBIOLOGY  Virion/METABOLISM  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

