       Document 0783
 DOCN  M9640783
 TI    Synchronous presentation of Epstein-Barr virus-associated Hodgkin's
       disease and adult T-cell leukemia/lymphoma (ATLL) in a patient from an
       endemic area of ATLL.
 DT    9604
 AU    Hayashi T; Yamabe H; Haga H; Akasaka T; Kadowaki N; Ohno H; Okuma M;
       Fukuhara S; Department of Internal Medicine, Kyoto University, Japan.
 SO    Int J Hematol. 1995 Jun;61(4):215-22. Unique Identifier : AIDSLINE
       MED/96164754
 AB    We report a patient from an endemic area of adult T-cell
       leukemia/lymphoma (ATLL), who developed lymphoma with features
       characteristic of Hodgkin's disease (HD). Large atypical
       Reed-Sternberg/Hodgkin's cells (RS/H cells) had a
       CD3-CD15+CD20-CD30+CD45RO- immunophenotype. Epstein-Barr virus (EBV)
       latent membrane protein and EBV-encoded small RNA were detected in the
       RS/H cells. The patient received C-MOPP/ABVD chemotherapy for the HD
       resulting in a partial response. However, relapse occurred and he died
       of disease progression associated with serious bacterial infection.
       Although serial lymph node biopsies revealed consistent presence of the
       EBV-positive RS/H cells, the background small lymphocytes showed
       progressive increase in pleomorphism and nuclear irregularity. The
       lymphocytes had the T-cell phenotype, CD3+CD4+CD7-CD8-. Southern blot
       analysis using DNA probes for the human T-cell lymphotrophic virus-I
       (HTLV-I) and the T-cell receptor beta-chain gene demonstrated expansion
       of the HTLV-I infected monoclonal T-cells with the disease progression.
       We concluded that the patient synchronously presented two independent
       lymphoproliferative disorders; EBV-associated HD and ATLL resulting from
       HTLV-I infection.
 DE    Antigens, CD/ANALYSIS  Antineoplastic Agents, Combined/ADVERSE
       EFFECTS/THERAPEUTIC USE  Bleomycin/ADMINISTRATION & DOSAGE  Case Report
       Cyclophosphamide/ADMINISTRATION & DOSAGE  Dacarbazine/ADMINISTRATION &
       DOSAGE  Doxorubicin/ADMINISTRATION & DOSAGE  Fatal Outcome
       Herpesviridae Infections/*COMPLICATIONS/VIROLOGY  Herpesvirus 4,
       Human/*ISOLATION & PURIF  Hodgkin's Disease/*COMPLICATIONS/DRUG THERAPY
       Human  HTLV-I/*ISOLATION & PURIF  Immunophenotyping  Japan/EPIDEMIOLOGY
       Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/
       *COMPLICATIONS/EPIDEMIOLOGY  Lymph Nodes/PATHOLOGY  Male  Middle Age
       Prednisone/ADMINISTRATION & DOSAGE  Procarbazine/ADMINISTRATION & DOSAGE
       Reed-Sternberg Cells/CHEMISTRY/VIROLOGY  RNA, Viral/ANALYSIS  Support,
       Non-U.S. Gov't  Tumor Stem Cells/CHEMISTRY  Tumor Virus
       Infections/*COMPLICATIONS/VIROLOGY  Vincristine/ADMINISTRATION & DOSAGE
       Viral Matrix Proteins/ANALYSIS  Virus Activation/DRUG EFFECTS  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

