       Document 0789
 DOCN  M9640789
 TI    Tuberculosis as an opportunistic disease in persons infected with human
       immunodeficiency virus.
 DT    9604
 AU    Castro KG; Division of Tuberculosis Elimination, Centers for Disease
       Control; and Prevention, Public Health Service, U.S. Department of
       Health; and Human Services, Atlanta, Georgia 30333, USA.
 SO    Clin Infect Dis. 1995 Aug;21 Suppl 1:S66-71. Unique Identifier :
       AIDSLINE MED/96002830
 AB    Tuberculosis, a bacterial disease caused by the Mycobacterium
       tuberculosis complex, is becoming an increasingly common opportunistic
       disease in persons infected with the human immunodeficiency virus (HIV).
       M. tuberculosis is transmitted from person-to-person by airborne droplet
       nuclei. Persons who are exposed to these droplet nuclei in poorly
       ventilated environments are at risk of becoming infected with M.
       tuberculosis. HIV infection is probably the most significant risk factor
       associated with progression from latent M. tuberculosis infection to
       active disease. Thus, HIV-infected persons should avoid exposure to M.
       tuberculosis, they should be screened for evidence of latent infection
       with the tuberculin skin test, and they should be offered preventive
       therapy. Because many severely immunosuppressed anergic HIV-infected
       persons have been found to have an increased risk of developing active
       tuberculosis, decisions to use preventive therapy should be
       individualized on the basis of the local prevalence of tuberculosis and
       drug-resistance patterns. Persons with active tuberculosis should
       receive at least 6 months of treatment with recommended regimens,
       preferably with directly observed therapy, to ensure adequate
       bacteriologic response, completion of therapy, and cure. Chronic
       suppressive therapy after completion of therapy is currently not
       recommended.
 DE    AIDS-Related Opportunistic Infections/*EPIDEMIOLOGY/PREVENTION &
       CONTROL/TRANSMISSION  Disease Transmission, Horizontal/PREVENTION &
       CONTROL  Human  Incidence  Infection Control/METHODS  Risk Factors
       Tuberculosis, Pulmonary/*EPIDEMIOLOGY/PREVENTION & CONTROL/
       TRANSMISSION  United States/EPIDEMIOLOGY  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

