       Document 0803
 DOCN  M9640803
 TI    Human papillomavirus infection and associated disease in persons
       infected with human immunodeficiency virus.
 DT    9604
 AU    Vernon SD; Holmes KK; Reeves WC; Division of Viral and Rickettsial
       Diseases, Centers for Disease; Control and Prevention, Atlanta, Georgia
       30333, USA.
 SO    Clin Infect Dis. 1995 Aug;21 Suppl 1:S121-4. Unique Identifier :
       AIDSLINE MED/96002840
 AB    Genital infection with human papillomavirus (HPV) is the most common
       sexually transmitted infection in the United States. Genital or anal
       infection with oncogenic types of HPV, particularly types 16 and 18, can
       cause precancerous lesions of the squamous epithelium. Infection with
       human immunodeficiency virus (HIV) increases the risk for HPV-associated
       genital neoplasias in both women and men. Detectable cervical and anal
       HPV infection is more prevalent among women and men with HIV infection
       than among those who are HIV-seronegative, and the magnitude of the
       increase in prevalence is proportionate to the severity of
       immunosuppression. Coinfection with HIV and HPV increases the risk for
       genital intraepithelial neoplasia, and the increase in this risk also
       reflects the severity of immunosuppression. One difficulty complicating
       elucidation of the association between HIV and HPV infections is that
       the risk factors for acquisition and transmission of the two viruses are
       similar. The strength of this association represents a burgeoning health
       problem, yet there are no treatment guidelines aimed specifically at
       HIV-infected individuals with HPV-associated genital neoplasias.
       Treatment of HPV-associated cervical disease in HIV-infected women may
       be further complicated by a greater risk of treatment failure and
       recurrence than exists among HIV-seronegative women; it is not known
       whether dysplasia progresses to invasive disease more rapidly in women
       infected with HIV. A thorough understanding of the associations among
       HIV, HPV, and HPV-associated disease is essential to the development of
       effective strategies for intervention and prevention.
 DE    Female  Genital Diseases, Female/*EPIDEMIOLOGY/PREVENTION & CONTROL
       Genital Diseases, Male/*EPIDEMIOLOGY/PREVENTION & CONTROL  Human  HIV
       Infections/*COMPLICATIONS  Incidence  Male  *Papillomavirus, Human
       Papovaviridae Infections/*EPIDEMIOLOGY/PREVENTION & CONTROL/
       TRANSMISSION  Risk Factors  Sexually Transmitted Diseases,
       Viral/*EPIDEMIOLOGY/PREVENTION &  CONTROL/TRANSMISSION  Tumor Virus
       Infections/*EPIDEMIOLOGY/PREVENTION & CONTROL/  TRANSMISSION  United
       States/EPIDEMIOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

