       Document 0820
 DOCN  M9640820
 TI    Intralesional interferon for the treatment of recalcitrant molluscum
       contagiosum in HIV antibody positive individuals--a preliminary report.
 DT    9604
 AU    Nelson MR; Chard S; Barton SE; Department of HIV/Genitourinary Medicine,
       Chelsea & Westminster; Hospital, London, UK.
 SO    Int J STD AIDS. 1995 Sep-Oct;6(5):351-2. Unique Identifier : AIDSLINE
       MED/96122193
 AB    Molluscum contagiosum is common in HIV disease and available therapies
       have a poor success rate and require frequent clinic visits. Interferon
       alpha has been used to treat recalcitrant condylomata acuminata and this
       study was undertaken to assess the use of this treatment in unresponsive
       molluscum contagiosum. A total of 30 molluscum contagiosum were injected
       with one megaunit of interferon alpha weekly for 4 weeks; 11 molluscum
       contagiosum completely cleared and 18 reduced in size by over 50%.
       Molluscum less than 0.5 cm in diameter, and those in patients without
       AIDS were more likely to respond. No surrounding lesions changed in
       size.
 DE    Antiviral Agents/*THERAPEUTIC USE  AIDS-Related Opportunistic
       Infections/IMMUNOLOGY/*THERAPY  CD4 Lymphocyte Count  Female  Human
       Injections, Intralesional  Interferon-alpha/*THERAPEUTIC USE  Male
       Molluscum Contagiosum/IMMUNOLOGY/*THERAPY  Treatment Failure  CLINICAL
       TRIAL  CONTROLLED CLINICAL TRIAL  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

