       Document 0837
 DOCN  M9640837
 TI    Zidovudine adherence among individuals with HIV infection.
 DT    9604
 AU    Muma RD; Ross MW; Parcel GS; Pollard RB; Department of Physician
       Assistant, College of Health Professions,; Wichita State University,
       Kansas 67260-0043, USA.
 SO    AIDS Care. 1995;7(4):439-47. Unique Identifier : AIDSLINE MED/96119351
 AB    The objective was to investigate the relationships among health beliefs,
       attitudes, and zidovudine compliance in individuals with HIV infection.
       A survey was administered to 52 individuals with HIV infection. The
       survey items, which reflected concerns expressed about zidovudine, were
       generated based on barriers to and benefits of zidovudine and the
       perceived susceptibility to and perceived severity of HIV as described
       by the health belief model (HBM). These items were expressed as
       attitudes and beliefs. Items were subjected to factor analysis, and
       survey results were correlated with laboratory data to predict adherence
       to their prescribed medication-taking regimen. Data indicated that 42.3%
       of the subjects were compliant with zidovudine. Factor analysis
       identified four dimensions: problems taking and scepticism about
       zidovudine; degree of concern about HIV; perceived severity of HIV; and
       physical barriers to taking zidovudine. Logistic regression analysis
       (forward conditional entry) identified those who were having problems
       taking zidovudine and who were sceptical about its effectiveness, and
       ethnicity as significant independent predictors of compliance, correctly
       classifying 75% of cases (p < 0.01). The fact that subjects who have
       problems taking zidovudine or are sceptical about the value of
       zidovudine are less compliant, and that this dimension is a significant
       predictor of compliance, suggests that non-compliance is related to
       attitudes and beliefs about zidovudine. This is consistent with the HBM,
       which holds that the balance between barriers and benefits of a
       health-related behaviour are significant determinants of outcome.
 DE    Adult  Antiviral Agents/*THERAPEUTIC USE  Attitude to Health  Blacks
       Cross-Sectional Studies  Culture  Factor Analysis, Statistical  Female
       Human  HIV Infections/*DRUG THERAPY  Logistic Models  Male  Middle Age
       Models, Psychological  *Patient Compliance  Reverse Transcriptase
       Inhibitors/*THERAPEUTIC USE  Texas  Zidovudine/*THERAPEUTIC USE  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

