       Document 0845
 DOCN  M9640845
 TI    EBV-associated lymphoproliferative syndrome with a distinct 69 base-pair
       deletion in the LMP-1 oncogene.
 DT    9604
 AU    Klein C; Rothenberger S; Niemeyer C; Bachmann E; Odermatt B; Bohm N;
       Brandis M; Knecht H; University Children's Hospital, Freiburg, Germany.
 SO    Br J Haematol. 1995 Dec;91(4):938-40. Unique Identifier : AIDSLINE
       MED/96136096
 AB    We describe an immunocompetent 12-year-old boy with chronic EBV
       infection and lymphoid interstitial pneumonitis. Lymph node biopsies
       showed effacement of the architecture with polymorphic cellular
       infiltrates, consisting predominantly of T cells and natural killer
       cells. No clonal rearrangement of TCR or immunoglobulin genes was seen.
       DNA was extracted from hilar lymph nodes; sequencing of the carboxy
       terminal region of the latent membrane protein 1 (LMP-1) oncogene
       revealed a 69 base-pair deletion and four point mutations.
       Immunosuppressive treatment with prednisone and cyclosporine reversed
       the lymphadenopathy.
 DE    Base Composition  Base Sequence  Case Report  Child
       Cyclosporine/THERAPEUTIC USE  DNA Primers/GENETICS  Electrophoresis,
       Agar Gel  *Gene Deletion  Herpesviridae Infections/DRUG
       THERAPY/*GENETICS/PATHOLOGY  Herpesvirus 4, Human/*IMMUNOLOGY  Human
       Lung Diseases, Interstitial/DRUG THERAPY/GENETICS/PATHOLOGY  Lymph
       Nodes/PATHOLOGY  Male  Molecular Sequence Data  Point Mutation
       Polymerase Chain Reaction  Prednisolone/THERAPEUTIC USE  Support,
       Non-U.S. Gov't  Tumor Virus Infections/DRUG THERAPY/*GENETICS/PATHOLOGY
       Viral Matrix Proteins/*GENETICS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

