       Document 0846
 DOCN  M9640846
 TI    Expression of the human OX40 (hOX40) antigen in normal and neoplastic
       tissues.
 DT    9604
 AU    Durkop H; Latza U; Himmelreich P; Stein H; Institute of Pathology,
       Klinikum Benjamin Franklin, Free; University of Berlin, Germany.
 SO    Br J Haematol. 1995 Dec;91(4):927-31. Unique Identifier : AIDSLINE
       MED/96136093
 AB    The Ber-ACT35 mAb was raised against the human T-cell lymphotrophic
       virus (HTLV) 1-transformed, CD4+ HUT 102 cell line and recognizes the
       human homologue of the OX40 (hOX40) antigen. The analysis of the
       expression of hOX40 by immunohistochemical techniques in malignant
       lymphomas, carcinomas and non-malignant tissues of different organs
       shows that hOX40 expression was almost completely restricted to T
       lymphocytes. Besides T cells only a small subpopulation of macrophages
       in Langerhans' cell histiocytosis and a few blasts in B-cell
       non-Hodgkin's lymphoma (B-NHL) revealed a faint immunostaining with the
       Ber-ACT35 mAb. Furthermore, most of the hOX40+ T-cells are CD4+.
 DE    Carcinoma/IMMUNOLOGY  Cell Line, Transformed  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY  Flow
       Cytometry  Human  HTLV-I  Immunohistochemistry  Lymphoma/*IMMUNOLOGY
       Macrophages/IMMUNOLOGY  Receptors, Tumor Necrosis Factor/*ANALYSIS
       Support, Non-U.S. Gov't  T-Lymphocytes/*IMMUNOLOGY  Tissue Distribution
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

