       Document 0847
 DOCN  M9640847
 TI    Distribution of Kaposi's sarcoma herpesvirus sequences among lymphoid
       malignancies in Italy and Spain.
 DT    9604
 AU    Pastore C; Gloghini A; Volpe G; Nomdedeu J; Leonardo E; Mazza U; Saglio
       G; Carbone A; Gaidano G; Laboratorio di Medicina e Oncologia Molecolare,
       Dipartimento di; Scienze Biomediche e Oncologia Umana, Italy.
 SO    Br J Haematol. 1995 Dec;91(4):918-20. Unique Identifier : AIDSLINE
       MED/96136090
 AB    In this study we have tested the distribution of Kaposi's sarcoma
       herpesvirus (KSHV) DNA sequences throughout the spectrum of lymphoid
       neoplasia in Italy and Spain. 180 cases of lymphoid malignancies
       representative of the major histologic and immunophenotypic categories
       of B- and T-cell tumours were analysed by means of a polymerase chain
       reaction-based assay. KSHV sequences were consistently absent in all
       categories of lymphoid malignancies studied, with the exception of a
       subset of B-cell non-Hodgkin's lymphomas localizing in the pleural,
       pericardial or peritoneal cavities, and fulfilling the diagnostic
       criteria of body-cavity-based lymphoma. The selective and consistent
       association of KSHV sequences with cases of body-cavity-based lymphoma
       throughout the spectrum of lymphoid neoplasms suggests that KSHV may be
       involved in the pathogenesis of this peculiar type of lymphoid
       malignancy.
 DE    Base Sequence  DNA Primers/GENETICS  DNA, Viral/*ANALYSIS
       Herpesviridae/*GENETICS  Human  HIV Infections/COMPLICATIONS/VIROLOGY
       Italy  Lymphoma/VIROLOGY  Lymphoma, B-Cell/*VIROLOGY  Lymphoma,
       T-Cell/VIROLOGY  Molecular Sequence Data  Polymerase Chain Reaction
       Sarcoma, Kaposi's/*VIROLOGY  Spain  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

