       Document 0852
 DOCN  M9640852
 TI    Satisfactory remission achieved by PUVA therapy in a case of crisis-type
       adult T-cell leukaemia/lymphoma with generalized cutaneous leukaemic
       cell infiltration.
 DT    9604
 AU    Takemori N; Hirai K; Onodera R; Saito N; Yokota K; Kinouchi M; Takahashi
       H; Iizuka H; Third Department of Internal Medicine, Asahikawa Medical
       College,; Japan.
 SO    Br J Dermatol. 1995 Dec;133(6):955-60. Unique Identifier : AIDSLINE
       MED/96150409
 AB    We used PUVA therapy in a patient with crisis-type adult T-cell
       leukaemia/lymphoma and generalized cutaneous leukaemic cell
       infiltration. PUVA proved very effective in reducing leukaemic cells and
       in clearing the eruption. To understand the way in which PUVA produced a
       reduction in the number of leukaemic cells, we examined peripheral blood
       cells by light and electron microscopy. Light microscopy was of little
       help, but electron microscopy revealed that PUVA induced apoptosis-like
       changes in circulating leukaemic cells. This suggests that
       apoptosis-like changes in leukaemic cells might be the reason for the
       success of this treatment.
 DE    Apoptosis  Case Report  Human  Leukemia-Lymphoma, T-Cell, Acute,
       HTLV-I-Associated/*DRUG THERAPY/  PATHOLOGY  Leukemic Infiltration/*DRUG
       THERAPY  Male  Microscopy, Electron  Middle Age  *PUVA Therapy
       Skin/*PATHOLOGY  JOURNAL ARTICLE

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