       Document 0584
 DOCN  M9650584
 TI    The high prevalence of genital herpes among patients with genital ulcer
       disease in Uganda.
 DT    9605
 AU    Kamya MR; Nsubuga P; Grant RM; Hellman N; Department of Medicine, School
       of Medicine, Makerere University,; Kampala, Uganda.
 SO    Sex Transm Dis. 1995 Nov-Dec;22(6):351-4. Unique Identifier : AIDSLINE
       MED/96157999
 AB    BACKGROUND: Genital ulcer disease is a risk factor for transmission of
       human immunodeficiency virus. One-hundred consecutive Ugandan patients
       (median age, 25 years) with genital ulcer disease were examined to
       determine the prevalence of genital herpes and its relationship to human
       immunodeficiency virus seropositivity. GOAL OF THIS STUDY: To improve
       management, prevention, and control of genital ulcer disease, thus
       reducing human immunodeficiency virus infections attributable to genital
       ulcer disease. STUDY DESIGN: This was a prevalence study of genital
       herpes in a consecutive sample of an urban sexually transmitted disease
       clinic population. RESULTS: Forty-nine percent (48/98) of the patients
       had genital herpes (36% by direct fluorescent antigen and 13% by history
       of recurrent vesicles). There was a trend toward larger lesions in
       patients who were human immunodeficiency virus seropositive. Twelve
       percent (11/89) of patients had syphilis, and 30% (30/100) remained
       sexually active, despite the presence of active genital ulcer disease.
       Sixty-five percent of 89 patients tested had antibodies to human
       immunodeficiency virus. CONCLUSIONS: Genital herpes is a common cause of
       genital ulcer disease in patients attending sexually transmitted disease
       clinics in Uganda, and herpes ulcers may be more extensive among those
       who are infected with human immunodeficiency virus.
 DE    Adult  Chancroid/PREVENTION & CONTROL/*VIROLOGY  Female  Herpes
       Genitalis/*COMPLICATIONS/PREVENTION & CONTROL  Human  HIV
       Seropositivity/*COMPLICATIONS/TRANSMISSION  Male  Prevalence  Risk
       Factors  Support, Non-U.S. Gov't  Uganda/EPIDEMIOLOGY  Urban Health
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

