       Document 0174
 DOCN  M9650174
 TI    IgA subclasses in HIV disease: dichotomy between raised levels in serum
       and decreased secretion rates in saliva.
 DT    9605
 AU    Sweet SP; Rahman D; Challacombe SJ; Department of Oral Medicine and
       Pathology, UMDS Guy's Hospital,; London, UK.
 SO    Immunology. 1995 Dec;86(4):556-9. Unique Identifier : AIDSLINE
       MED/96165032
 AB    This study sought to determine IgA, IgA1 and IgA2 concentrations and
       secretion rates in unstimulated whole saliva and stimulated parotid
       saliva and IgA, IgA1 and IgA2 concentrations in serum from asymptomatic
       human immunodeficiency virus (HIV)-infected, acquired immune deficiency
       syndrome (AIDS) and control subjects. In whole and parotid saliva the
       mean IgA, IgA1 and IgA2 concentrations in the HIV and AIDS groups were
       lower than the control group (P < 0.05). Unstimulated whole and
       stimulated parotid saliva flow rates were lower in the HIV and AIDS
       groups compared with the control group, and reached statistical
       significance with respect to the mean parotid saliva flow rate in the
       AIDS group (P < 0.05). Mean IgA, IgA1 and IgA2 secretion rates in both
       the HIV and AIDS groups were significantly less than the controls (P <
       0.05). In contrast, serum IgA, IgA1 and IgA2 concentrations were
       markedly raised in the HIV and AIDS groups compared with the control
       group (P < 0.001). There was no correlation between saliva and serum IgA
       concentrations within individuals. This study suggests that, in spite of
       the raised, polyclonally activated serum IgA concentrations associated
       with HIV infection, salivary IgA concentrations and secretion rates are
       reduced, emphasizing the dichotomy between systemic and secretory
       immunity.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY  Adult  Aged  Case-Control
       Studies  Citrates/DIAGNOSTIC USE  Human  HIV Infections/*IMMUNOLOGY
       IgA/*BLOOD  IgA, Secretory/*METABOLISM  Male  Middle Age  Parotid
       Gland/IMMUNOLOGY  Saliva/*IMMUNOLOGY  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

