       Document 0324
 DOCN  M9650324
 TI    Autopsy-proven causes of death in HIV-infected patients treated for
       tuberculosis in Abidjan, Cote d'Ivoire.
 DT    9605
 AU    Greenberg AE; Lucas S; Tossou O; Coulibaly IM; Coulibaly D; Kassim S;
       Ackah A; De Cock KM; Projet RETRO-CI, Abidjan, Cote d'Ivoire.
 SO    AIDS. 1995 Nov;9(11):1251-4. Unique Identifier : AIDSLINE MED/96126179
 AB    OBJECTIVE: To determine autopsy-proven causes of death in HIV-infected
       patients treated for tuberculosis in Abidjan, Cote d'Ivoire. METHODS: A
       computerized listing of 9523 patients diagnosed with tuberculosis and
       tested for HIV infection at Abidjan's two large tuberculosis treatment
       centers from July 1989 to December 1991 was matched against a listing of
       496 patients who were autopsied in Abidjan's largest public hospital in
       1991-1992. RESULTS: Fifteen matching patients were identified including
       11 adults with smear-positive pulmonary tuberculosis, three adults with
       extrapulmonary tuberculosis, and one child with smear-negative pulmonary
       tuberculosis. The autopsy-proven causes of death among the adults were
       tuberculosis (n = 4), bacterial infections (n = 3), cerebral
       toxoplasmosis (n = 2), pulmonary nocardiosis (n = 2), Pneumocystis
       carinii pneumonia (n = 1), atypical mycobacteriosis (n = 1), and wasting
       syndrome (n = 1). Tuberculosis was the primary cause of death in two of
       five smear-positive patients who had not completed therapy, in none of
       the six patients with smear-positive disease who had completed therapy,
       and in two of the three patients with extrapulmonary tuberculosis.
       CONCLUSIONS: Chemoprophylaxis with trimethoprim-sulfamethoxazole
       (TMP-SMX) might have provided benefit to eight (57%) of the 14 adults in
       this series who died either of bacterial infections, toxoplasmosis,
       nocardiosis, or pneumocystosis. Prospective studies are required to
       elucidate further the causes of increased mortality, and to evaluate the
       benefits of TMP-SMX prophylaxis in HIV-infected African patients with
       tuberculosis.
 DE    Adult  Autopsy  Cause of Death  Child, Preschool  Cote d'Ivoire  Female
       Human  HIV Infections/*COMPLICATIONS/MORTALITY  Male  Middle Age
       Tuberculosis/ETIOLOGY/MORTALITY/*PATHOLOGY  Tuberculosis,
       Pulmonary/ETIOLOGY/MORTALITY/*PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

