       Document 0348
 DOCN  M9650348
 TI    Elevated plasma concentration of reduced homocysteine in patients with
       human immunodeficiency virus infection.
 DT    9605
 AU    Muller F; Svardal AM; Aukrust P; Berge RK; Ueland PM; Froland SS;
       Medical Department A, University of Oslo, National Hospital,; Norway.
 SO    Am J Clin Nutr. 1996 Feb;63(2):242-8. Unique Identifier : AIDSLINE
       MED/96148838
 AB    Oxidative stress has been suggested to be an important factor in the
       immunopathogenesis of human immunodeficiency virus (HIV) infection.
       Reduced plasma thiols may lead to production of reactive oxygen species,
       thus contributing to the oxidative stress. We quantified the total,
       reduced, and protein-bound forms of the thiols homocysteine, cysteine,
       cysteinylglycine, and methionine in plasma from 21 HIV-infected patients
       and 15 healthy control subjects and compared the results with clinical
       and immunologic indexes. The HIV-infected patients had significantly
       higher concentrations of reduced homocysteine in plasma compared with
       control subjects. No significant differences in reduced homocysteine
       concentrations were noted when asymptomatic and symptomatic HIV-infected
       patients were compared, and we did not find any relation between reduced
       homocysteine concentrations and other markers of immunodeficiency. The
       HIV-infected patients had normal total homocysteine concentrations. The
       reduced cysteinylglycine concentration tended to be elevated in the
       patient group. No differences between HIV-infected patients and control
       subjects were found for reduced or total cysteine. Compared with control
       subjects, the HIV-infected patients had lower concentrations of
       methionine in plasma, and a significant correlation was found between
       low concentrations of methionine and low CD4+ lymphocyte counts in
       blood. Elevated concentrations of reduced homocysteine could possibly
       contribute to formation of reactive oxygen species, leading to
       accelerated immunologic deterioration and increased HIV replication.
 DE    Adult  Cysteine/BLOOD  CD4 Lymphocyte Count  Dipeptides/BLOOD  Female
       Folic Acid/BLOOD  Homocysteine/*BLOOD  Human  HIV Antibodies/ANALYSIS
       HIV Infections/*BLOOD/IMMUNOLOGY  *HIV-1/IMMUNOLOGY
       Interleukin-2/BIOSYNTHESIS  Lymphocytes/IMMUNOLOGY  Male
       Methionine/BLOOD  Middle Age  Oxidation-Reduction  Oxidative Stress
       Support, Non-U.S. Gov't  Vitamin B 12/BLOOD  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

