       Document 0060
 DOCN  M9490060
 TI    Candidal infection of the gingiva in HIV-infected persons.
 DT    9411
 AU    Odden K; Schenck K; Koppang H; Hurlen B; Department of Oral Biology,
       University of Oslo, Norway.
 SO    J Oral Pathol Med. 1994 Apr;23(4):178-83. Unique Identifier : AIDSLINE
       MED/94322277
 AB    Gingival biopsies were taken from 27 HIV (human immunodeficiency
       virus)-seropositive persons with gingivitis or periodontitis and 16
       HIV-seronegative persons with periodontitis. Sections were stained with
       hematoxylin and eosin or periodic acid-Schiff. Candidal hyphae and
       pseudohyphae were found in the parakeratinized oral epithelium in 7
       specimens from the HIV-infected patient group such specimen. No fungal
       invasion was found in any of the biopsies from the HIV-seronegative
       persons. Candidal invasion was significantly more frequent (P < 0.05) in
       patients with a confirmed history of necrotizing periodontal diseases
       (5/9) than in patients without known episodes of such diseases (3/18).
       The most prominent histopathologic changes observed in connection with
       candidal invasion comprised polymorphonuclear leucocyte infiltration of
       the oral gingival epithelium and numerous mitoses, some of which were
       located suprabasally. It is suggested that Candida albicans may
       contribute to the development of necrotizing periodontal diseases in
       HIV-infected persons.
 DE    Adult  AIDS-Related Opportunistic Infections/*PATHOLOGY  Candida/GROWTH
       & DEVELOPMENT  Candidiasis, Oral/*PATHOLOGY  Connective Tissue/PATHOLOGY
       Epithelium/PATHOLOGY  Female  Gingiva/MICROBIOLOGY/PATHOLOGY  Gingival
       Hemorrhage/MICROBIOLOGY/PATHOLOGY  Gingivitis/*MICROBIOLOGY/PATHOLOGY
       Human  HIV Infections/*PATHOLOGY  HIV Seronegativity  Male  Middle Age
       Necrosis  Neutrophils/PATHOLOGY  Periodontitis/MICROBIOLOGY/PATHOLOGY
       Ulcer/MICROBIOLOGY/PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

