       Document 0122
 DOCN  M9490122
 TI    Transfusion-transmitted human T-cell lymphotropic virus type I infection
       in Taiwan: a true risk and occasional coinfection with hepatitis C virus
       shown in a prospective study.
 DT    9411
 AU    Wang JT; Lin MT; Chen PJ; Sheu JC; Lin JT; Wang TH; Chen DS; Department
       of Internal Medicine, National Taiwan University; Hospital, Taipei.
 SO    Blood. 1994 Aug 1;84(3):934-40. Unique Identifier : AIDSLINE
       MED/94318974
 AB    To study the incidence of human T-cell lymphotropic virus (HTLV) after
       blood transfusion in Taiwan, serum samples from 699 patients in a
       prospective study were examined for seroreactivity of anti-HTLV. By an
       enzyme immunoassay, 9 of the 699 recipients were repeatedly positive.
       Serial serum samples of these 9 patients were then confirmed with a
       Western blot analysis and with a polymerase chain reaction (PCR) assay
       for HTLV-I genome. Four were already positive for anti-HTLV before
       transfusion, 1 carried antibodies to HTLV-I transiently after
       transfusion, and only 4 cases had de nova seroconversions. These
       patients and their family members were called back and tested for HTLV-I
       genome in the peripheral blood mononuclear cell (PBMC) and plasma. All
       the serologically positive patients, except the transient one, were
       positive for HTLV sequences in the PBMCs. Viral sequences could also be
       detected in several serum or plasma samples. In the family members, only
       the spouse of a pretransfusion-positive patient was infected. These
       results suggested that approximately 0.6% of the blood recipients were
       infected by HTLV-I through transfusion in Taiwan, and that the frequency
       of intrafamilial HTLV-I transmission is low. We also observed the
       unusual coinfection by both HTLV-I and hepatitis C virus in 2 patients,
       and superinfection of hepatitis C virus after blood transfusion in 1
       HTLV-I carrier. Cases of coinfection suggest a prevalence of both
       viruses in blood donors and warrant further screening.
 DE    Adolescence  Adult  Aged  Base Sequence  *Blood Donors  Blood
       Transfusion/*ADVERSE EFFECTS  DNA Primers/CHEMISTRY  DNA, Viral/ANALYSIS
       Hepatitis C/*TRANSMISSION  Human  HTLV Antibodies/*ANALYSIS
       HTLV-I/GENETICS  HTLV-I Infections/*TRANSMISSION  Middle Age  Molecular
       Sequence Data  Prospective Studies  Support, Non-U.S. Gov't  Taiwan
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

