       Document 0123
 DOCN  M9490123
 TI    Mutations in the coding region of c-myc occur frequently in acquired
       immunodeficiency syndrome-associated lymphomas.
 DT    9411
 AU    Bhatia K; Spangler G; Gaidano G; Hamdy N; Dalla-Favera R; Magrath I;
       Lymphoma Biology Section, National Cancer Institute, National;
       Institutes of Health, Bethesda, MD 20892.
 SO    Blood. 1994 Aug 1;84(3):883-8. Unique Identifier : AIDSLINE MED/94318966
 AB    We have analyzed 30 cases of high- and intermediate-grade acquired
       immunodeficiency syndrome-associated non-Hodgkin's lymphoma (AIDS-NHL)
       for mutations in the c-myc coding region. In addition, in these same
       tumors, we have sought the presence of mutations in a regulatory region
       within the first c-myc intron defined by the binding to a factor that
       inhibits c-myc transcription (MYC intron factor, or mif). Mutations in
       the c-myc coding region were present in 10 of 16 small noncleaved cell
       lymphoma (SNCL), but in only 3 of 14 other histologic subtypes tested
       (0/3 large non-cleaved cell, 2/8 immunoblastic, and 1/3 anaplastic large
       cell lymphomas). Nineteen of the AIDS-NHLs analyzed contained a c-myc
       rearrangement and in 10 of these the c-myc gene was mutated in its
       coding region. In contrast, we could detect a mutation in the coding
       region in only 2 of 8 AIDS-NHL without a c-myc rearrangement. Mutations
       in the mif region were detected in 5 of 16 SNCL. Among AIDS-NHL carrying
       mutations in the c-myc coding region, only 4 carried mutations in the
       regulatory region. These results suggest that the mutations in the
       coding region of the c-myc protein may either be a consequence of the
       translocations involving c-myc, or may be necessary only in tumors where
       c-myc is deregulated as a result of a c-myc/lg translocation.
 DE    Base Sequence  DNA Primers/CHEMISTRY  Exons  *Genes, myc  Human
       Lymphoma, AIDS-Related/*GENETICS  Molecular Sequence Data  Mutation
       Regulatory Sequences, Nucleic Acid  Support, Non-U.S. Gov't  Support,
       U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

