       Document 0298
 DOCN  M94A0298
 TI    [Sputum examination in the diagnosis of Pneumocystis carinii pneumonia
       in HIV-infected patients]
 DT    9412
 AU    Schlatter CE; Kuster H; Luthy R; Weber R; Russi EW; Opravil M;
       Departement Innere Medizin, Universitatsspital Zurich.
 SO    Dtsch Med Wochenschr. 1994 Aug 26;119(34-35):1151-5. Unique Identifier :
       AIDSLINE MED/94357054
 AB    To assess the sensitivity and negative predictive value of sputum
       examination for Pneumocystis carinii in HIV-positive patients,
       follow-ups were performed in HIV-infected patients who had been
       investigated for the presence of Pneumocystis carinii (376 examinations
       of sputum and 71 bronchoalveolar lavages). Pneumocystis carinii
       pneumonia was diagnosed 65 times in 64 patients (57 male and 7 female,
       median age 35 [23-67]years). In 52% of the cases (n = 34) the pathogen
       was identified in the sputum, in 48% (n = 31) by means of the
       bronchoalveolar lavage. Of 342 negative findings in sputum examination,
       five were definitely false negative since the subsequent lavage yielded
       pneumocysts. In nine further cases Pneumocystis carinii pneumonia could
       not be excluded because of the course of the disease. In patients from
       whom sputum samples were available the sensitivity of pathogen
       identification was at least 70.8% and the negative predictive value at
       least 95.9%. Since preceding prophylaxis did not render identification
       in the sputum more difficult, examination of spontaneous or provoked
       sputum is indicated as a first hand measure in all patients infected
       with HIV in whom Pneumocystis carinii pneumonia is suspected.
 DE    Adult  Aged  AIDS-Related Opportunistic
       Infections/*DIAGNOSIS/EPIDEMIOLOGY  Bronchoalveolar Lavage
       Fluid/MICROBIOLOGY  Chi-Square Distribution  English Abstract  False
       Negative Reactions  Female  Follow-Up Studies  Human  HIV
       Infections/*COMPLICATIONS/EPIDEMIOLOGY  *HIV-1  Male  Middle Age
       Pneumocystis carinii/*ISOLATION & PURIF  Pneumonia, Pneumocystis
       carinii/*DIAGNOSIS/EPIDEMIOLOGY  Retrospective Studies  Sensitivity and
       Specificity  Sputum/*MICROBIOLOGY  Switzerland/EPIDEMIOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

