       Document 0313
 DOCN  M94A0313
 TI    Stroke and cerebral infarcts in children infected with human
       immunodeficiency virus.
 DT    9412
 AU    Philippet P; Blanche S; Sebag G; Rodesch G; Griscelli C; Tardieu M;
       Service of Pediatric Immunology and Hematology, Hopital; Necker-Enfants
       Malades, Paris, France.
 SO    Arch Pediatr Adolesc Med. 1994 Sep;148(9):965-70. Unique Identifier :
       AIDSLINE MED/94356160
 AB    OBJECTIVE: To study the causes of stroke and cerebral infarcts in
       children infected with the human immunodeficiency virus (HIV)-type 1.
       DESIGN: Case series. PATIENTS: Four of 380 HIV-infected children
       followed up in a 10-year period in our department who had a stroke with
       evidence of cerebral infarcts on radiological imaging. RESULTS: The four
       patients were severely immunodepressed, but their clinical status and
       outcome were different. Aneurysmal dilation of major cerebral arteries
       and thrombosis of these arteries or of small cortical vessels were
       discovered in two patients. Both patients had a history of frequent
       infections and had suffered repeated neurological events that resulted
       in severe clinical deterioration or death. An infectious causative agent
       was strongly suspected but was not detected. The other two patients had
       a more favorable outcome. An isolated cerebrovascular thrombosis was
       found in one patient, while in the other, HIV-1-related focal necrosis
       was suggested by the lack of permanent cerebrovascular abnormalities or
       thrombosis and by signs of necrosis in biopsy specimens of the brain.
       CONCLUSION: Stroke and cerebral infarcts in HIV-1 infected children have
       different causes and different prognoses.
 DE    Adolescence  Antigens, CD4  Brain/PATHOLOGY  Case Report  Cerebral
       Infarction/*ETIOLOGY/PATHOLOGY  Cerebrovascular
       Disorders/*ETIOLOGY/RADIOGRAPHY  Child  Child, Preschool  Fatal Outcome
       Female  Follow-Up Studies  Human  HIV Infections/*COMPLICATIONS  *HIV-1
       Magnetic Resonance Imaging  Male  Prognosis  Tomography, X-Ray Computed
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

