       Document 0103
 DOCN  M9550103
 TI    Evidence that cytokine-mediated immune interactions induced by
       Schistosoma mansoni alter disease outcome in mice concurrently infected
       with Trichuris muris.
 DT    9505
 AU    Curry AJ; Else KJ; Jones F; Bancroft A; Grencis RK; Dunne DW; Department
       of Pathology, University of Cambridge, United Kingdom.
 SO    J Exp Med. 1995 Feb 1;181(2):769-74. Unique Identifier : AIDSLINE
       MED/95138709
 AB    In murine models of Schistosoma mansoni infection, egg production is
       associated with a switch from T helper cell (Th)1- to Th2-type responses
       to both schistosome-specific and unrelated antigens. Polyparasitism is
       common in human populations within S. mansoni endemic areas. We have,
       therefore, examined whether coinfection with S. mansoni could affect the
       outcome of a second parasitic infection, through Th2 cytokine-dependent
       modifications to the host immune response. We find that when mice
       susceptible to infection with the gut nematode Trichuris muris are
       coinfected with S. mansoni, they acquire the capacity to resolve T.
       muris infection, thus demonstrating a resistant phenotype. This ability
       to expel T. muris is associated with the production of Th2-associated
       cytokines, and corresponding antibody isotypes, in response to S.
       mansoni egg antigens. The Th2 response shows that there is no
       compartmentalization between spleen and mesenteric lymph nodes, and that
       the expulsion of T. muris is not caused by any changes in the host
       intestine associated with excretion of schistosome eggs. This influence
       of schistosome infections may be important, not only for the outcome of
       infections with unrelated pathogens in endemic areas, but also for the
       efficacy of vaccines in such areas.
 DE    Animal  Antibodies, Helminth/IMMUNOLOGY  Cytokines/*IMMUNOLOGY
       Down-Regulation (Physiology)  Human  Intestines/PATHOLOGY  Mice  Mice,
       Inbred AKR  *Schistosoma mansoni
       Schistosomiasis/COMPLICATIONS/*IMMUNOLOGY  Support, Non-U.S. Gov't  Th1
       Cells/IMMUNOLOGY  Th2 Cells/IMMUNOLOGY
       Trichuriasis/COMPLICATIONS/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

