       Document 0185
 DOCN  M9550185
 TI    Maternal factors associated with perinatal HIV-1 transmission: the
       French Cohort Study: 7 years of follow-up observation. The French
       Pediatric HIV Infection Study Group.
 DT    9505
 AU    Mayaux MJ; Blanche S; Rouzioux C; Le Chenadec J; Chambrin V; Firtion G;
       Allemon MC; Vilmer E; Vigneron NC; Tricoire J; et al; Hopital Kremlin
       Bicetre, France.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):188-94.
       Unique Identifier : AIDSLINE MED/95135997
 AB    A nationwide, longitudinal study of infants born to human
       immunodeficiency virus-seropositive mothers has been under way in France
       since 1986. After 7 years of follow-up observations, we will update our
       assessment of the transmission rate in France and analyze, on a larger
       number of mother-infant pairs, the influence of maternal factors. Among
       the 848 pairs included in this analysis, the transmission rate was 20.2
       +/- 2.7%. The transmission rate has remained stable with time and was
       not influenced by the mode of delivery, the mode of maternal infection,
       or the mother's ethnic origin. It was twice as high among the breast-fed
       infants as among the bottle-fed infants (40 vs. 19%, p < 0.04). Two
       factors were identified in a multivariate analysis (that did not include
       lymphocyte subset counts and the mode of feeding) as being associated
       with an increased risk of maternofetal transmission: p24 antigenemia
       (odds ratio = 3.1, confidence interval, = 1.5-6.2; p < 0.003) and
       elevated maternal age (p < 0.05). In the subgroup of 277 women whose
       absolute CD4+ lymphocyte counts at the time of delivery were available,
       the risk of transmission increased gradually from 15% of counts of > 600
       CD4+ cells to 43% at counts of < 200. The risk of transmission was also
       related to the percentage of CD8+ cells, but each of the two factors
       seemed to play an independent role: the risk was lowest (12%) when the
       CD4+ cell count was > 500 and the proportion of CD8+ cells was < or =
       40%, and was highest (50%) for values < 200 and > 40%.(ABSTRACT
       TRUNCATED AT 250 WORDS)
 DE    Adult  Child  Child, Preschool  CD4 Lymphocyte Count  CD8-Positive
       T-Lymphocytes  *Disease Transmission, Vertical  Female  France  Human
       HIV Infections/CLASSIFICATION/EPIDEMIOLOGY/*TRANSMISSION  HIV
       Seropositivity/DIAGNOSIS  *HIV-1  Infant  Infant, Newborn  Longitudinal
       Studies  Multivariate Analysis  Pregnancy  Risk Factors  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE  MULTICENTER STUDY

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

